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    Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway

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    Publication date
    2009-07-14T13:47:00Z
    Author
    Sharov, A.A.
    Fessing, Michael Y.
    Atoyan, R.
    Sharova, T.Y.
    Haskell-Luevano, C.
    Weiner, L.
    Funa, K.
    Brissette, J.L.
    Gilchrest, B.A.
    Botchkarev, Vladimir A.
    Keyword
    Hair Follicle
    Melanocyte
    Noggin
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Hair pigmentation is controlled by tightly coordinated programs of melanin synthesis and involves signaling through the melanocortin type 1 receptor (MC-1R) that regulates the switch between pheomelanogenesis and eumelanogenesis. However, the involvement of other signaling systems, including the bone morphogenetic protein (BMP) pathway, in the control of hair pigmentation remains to be elucidated. To assess the effects of BMP signaling on hair pigmentation, transgenic mice overexpressing the BMP antagonist noggin (promoter: keratin 5) were generated. Whereas wild-type C3H/HeJ mice have a subapical yellow band on otherwise black dorsal hairs, K5-Noggin mice are characterized by the absence of a yellow band and near-black pigment in dorsal coat. Noggin overexpression is accompanied by strongly reduced levels of Agouti signal protein and enhanced expression of microphthalmia transcription factor in the midphase of the hair-growth cycle. Wild-type color in K5-Noggin mice is restored by administration of a synthetic MC-1R antagonist resulting in the reappearance of a subapical yellow band. BMP-4 stimulates the expression of Agouti transcripts and protein in primary epidermal keratinocytes, and BMP signaling positively regulates dermal papilla-specific enhancer of the Agouti gene in primary dermal fibroblasts. Taken together, these data suggests that BMP signaling controls the expression of Agouti protein in the hair follicle and provide evidence for interaction between BMP and MC-1R signaling pathways to modulate the balance between pheomelanogenesis and eumelanogenesis during hair growth.
    URI
    http://hdl.handle.net/10454/3009
    Version
    No full-text available in the repository
    Citation
    Sharov AA, Fessing M, Atoyan R, et al (2005). Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway. Proceedings of the National Academy of Sciences. 102 (1): 93-98.
    Link to publisher’s version
    https://doi.org/10.1073/pnas.0408455102
    Type
    Article
    Collections
    Life Sciences Publications

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