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    Anti-vascular effects of vinflunine in the MAC 15A transplantable adenocarcinoma model.

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    Publication date
    2001
    Author
    Bibby, Michael C.
    Hill, B.T.
    Holwell, S.E.
    Keyword
    Adenocarcinoma prevention and control
    Angiogenesis Inhibitors pharmacology
    Antineoplastic Agents
    Phytogenic pharmacology
    Vinblastine analogs and derivatives
    Vinblastine pharmacology
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Anti-vascular effects of the novel Vinca alkaloid, vinflunine have been investigated in the MAC 15A transplantable murine colon adenocarcinoma model and compared with those induced by the most recently identified clinically useful third generation Vinca. Administration of the maximum tolerated dose of either vinflunine (50 mg kg-1) or vinorelbine (8 mg kg-1) resulted in significant tumour growth delay with subsequent histological analysis revealing substantial haemorrhagic necrosis. This suggested possible anti-vascular effects and these were confirmed by Hoechst 33342 perfusion studies. Vinflunine, currently undergoing Phase I trials in Europe, was found to be at least as effective as the clinically active vincristine and vinorelbine in this model and, remarkably, produced anti-vascular effects at doses much lower than the maximum tolerated dose. Although vinflunine caused apoptosis in HUVEC monolayer cultures this event did not occur within the first 8 hours of exposure whereas vascular shutdown in vivo was observed within the first 4 hours.
    URI
    http://hdl.handle.net/10454/2991
    Version
    No full-text available in the repository
    Citation
    Bibby, M.C., Hill, B.T. and Holwell, S.E. (2001). Anti-vascular effects of vinflunine in the MAC 15A transplantable adenocarcinoma model. British Journal of Cancer. Vol. 84, No. 2, pp. 290-295.
    Link to publisher’s version
    http://www.nature.com/bjc/journal/v84/n2/abs/6691587a.html
    Type
    Article
    Collections
    Life Sciences Publications

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