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    SCF - Engineered powders for delivery of budesonide from passive DPI devices.

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    Publication date
    2005
    Author
    York, Peter
    Lobo, J.M.
    Palakodaty, S.
    Schiavone, H.
    Clark, A.
    Tzannis, S.T.
    Keyword
    Delivery system
    Corticosteroid
    Antiinflammatory agent
    Pharmaceutical technology
    Inhaler
    Intrapulmonary administration
    Particle
    Budesonide
    Powder
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    The objective of this study was to develop SEDS-engineered budesonide particles suitable for dry powder inhalation delivery and to evaluate their aerosol performance across a range of passive dry powder inhalers (DPI). SEDS budesonide powders were manufactured in Nektar's SCF manufacturing plant and compared to the micronized drug and commercial powder (Pulmicort Turbuhaler, AstraZeneca). Aerosol performance was evaluated by determining emitted dose (ED) by a variation of the USP method and fine particle fraction (FPF) using Andersen cascade impaction. The SCF powder dispersed best in the Turbospin and Eclipse devices, exhibiting high EDs (70%-80%) and relatively low variability (RSD 8%-13%). Regardless of the device, the SEDS material outperformed both the micronized drug and the commercial powder, while exhibiting good batch-to-batch reproducibility (RSD <5%). All powders exhibited flow rate-dependent ED, albeit for the SEDS material it was minimized at reduced fill weights. This was attributed to inadequate and variable powder clearance from the capsules at low inspiratory flow rates, which was more pronounced in the Eclipse and Cyclohaler. The results demonstrate that SEDS is an attractive particle-engineering process that may enhance pulmonary performance of budesonide and possibly facilitate development of other small molecule pulmonary products in passive DPI.
    URI
    http://hdl.handle.net/10454/2958
    Version
    No full-text available in the repository
    Citation
    York, P., Lobo, J.M., Palakodaty, S. and Clark, A. et al. (2005). SCF - Engineered powders for delivery of budesonide from passive DPI devices. Journal of Pharmaceutical Sciences. Vol. 94, No. 10, pp. 2276-2288.
    Link to publisher’s version
    http://www3.interscience.wiley.com/cgi-bin/fulltext/111084446/PDFSTART
    Type
    Article
    Collections
    Life Sciences Publications

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