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    Asymmetric propagation of spreading depression along the anteroposterior axis of the cerebral cortex in mice.

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    Publication date
    2001
    Author
    Obrenovitch, Tihomir P.
    Godukhin, O.V.
    Keyword
    Asymmetric propagation
    Spreading depression
    Mice
    Cerebral cortex
    Antiposterior axis
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    The purpose of this study was to ascertain whether or not spreading depression (CSD) propagates symmetrically along the anteroposterior axis of the cortex of mice, and to determine where CSD should be elicited to achieve a uniform exposure of the cortex to this phenomenon. Experiments were performed in halothane-anesthetized mice, with three different locations aligned 1.5 mm from the midline used for either KCl elicitation of CSD or the recording of its propagation. Our results demonstrated that, at least in the mouse cortex, CSD propagated much more effectively from posterior to anterior regions than in the opposite direction. This feature was due to a different efficacy of propagation in the two opposite directions, and not to a reduced susceptibility of occipital regions to CSD elicitation. Heterogeneous CSD propagation constitutes a potential pitfall for neurochemical studies of post-CSD changes in mice, as brain tissue samples collected for this purpose should be uniformly exposed to CSD. Occipital sites for CSD induction are clearly optimal for this purpose. If CSD propagation is confirmed to be more effective from posterior to anterior regions in other species, this may be relevant to the pathophysiology of classical migraine because the most frequent aura symptoms (i.e., visual disturbances) originate in the occipital cortex.
    URI
    http://hdl.handle.net/10454/2889
    Version
    No full-text available in the repository
    Citation
    Obrenovitch, T.P. and Godulchin, O.V. (2001). Asymmetric propagation of spreading depression along the anteroposterior axis of the cerebral cortex in mice. Journal of Neurophysiology. Vol.86, No. 4, pp. 2109-2111.
    Link to publisher’s version
    http://jn.physiology.org/cgi/reprint/86/4/2109http://jn.physiology.org/cgi/reprint/86/4/2109
    Type
    Article
    Collections
    Life Sciences Publications

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