The role of endothelial cell reactive antibodies in peripheral arterial disease
Publication date
2006Keyword
IschaemiaPeripheral vascular disease
Endothelial cell reactive antibodies
Peripheral arterial disease
Anticardiolipin
Anti-ß2-glycoprotein I
Interleukin-6
Peer-Reviewed
Yes
Metadata
Show full item recordAbstract
Objectives It is hypothesised that endothelial cell reactive antibodies (ECRA) play a role in the progression of PAD through activation of endothelial cells and the release of inflammatory cytokines. We aimed to test this hypothesis by assessing levels of ECRA, E-selectin and IL-6 in patients with PAD of varying severity in a case controlled study. Design, materials, methods Patients were assessed clinically and with ankle¿brachial pressure indices. Patients with critical ischaemia (CI, n=30), stable claudicants (SC, n=30), and age-matched controls (AMC, n=20) were studied. Antibody, E-selectin and IL-6 levels were measured using ELISA. Results ECRA levels were significantly raised in the CI group over AMC. IL-6 levels were significantly elevated in both SC and CI over the control group and in CI over SC. There were no significant differences in E-selectin levels between the AMC, SC and CI. Conclusion Our findings support the hypothesis that autoantibodies play a role in promoting PAD by elevating IL-6. The absence of an elevation in E-selectin in this study may be due to its short half-life, and casts doubt on its value as a marker of inflammation in atherosclerosis.Version
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Lindsey, N.J., Armitage, J.D. and Horner-Vanniasinkam S. (2006). The role of endothelial cell reactive antibodies in peripheral arterial disease. European Journal of Vascular and Endovascular Surgery. Vol. 31, No. 2, pp. 170-175.Link to Version of Record
https://doi.org/10.1016/j.ejvs.2005.05.044Type
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1016/j.ejvs.2005.05.044