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    The role of endothelial cell reactive antibodies in peripheral arterial disease

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    Publication date
    2006
    Author
    Lindsey, Nigel J.
    Armitage, J.D.
    Homer-Vanniasinkam, Shervanthi
    Keyword
    Ischaemia
    Peripheral vascular disease
    Endothelial cell reactive antibodies
    Peripheral arterial disease
    Anticardiolipin
    Anti-ß2-glycoprotein I
    Interleukin-6
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Objectives It is hypothesised that endothelial cell reactive antibodies (ECRA) play a role in the progression of PAD through activation of endothelial cells and the release of inflammatory cytokines. We aimed to test this hypothesis by assessing levels of ECRA, E-selectin and IL-6 in patients with PAD of varying severity in a case controlled study. Design, materials, methods Patients were assessed clinically and with ankle¿brachial pressure indices. Patients with critical ischaemia (CI, n=30), stable claudicants (SC, n=30), and age-matched controls (AMC, n=20) were studied. Antibody, E-selectin and IL-6 levels were measured using ELISA. Results ECRA levels were significantly raised in the CI group over AMC. IL-6 levels were significantly elevated in both SC and CI over the control group and in CI over SC. There were no significant differences in E-selectin levels between the AMC, SC and CI. Conclusion Our findings support the hypothesis that autoantibodies play a role in promoting PAD by elevating IL-6. The absence of an elevation in E-selectin in this study may be due to its short half-life, and casts doubt on its value as a marker of inflammation in atherosclerosis.
    URI
    http://hdl.handle.net/10454/2888
    Version
    No full-text available in the repository
    Citation
    Lindsey, N.J., Armitage, J.D. and Horner-Vanniasinkam S. (2006). The role of endothelial cell reactive antibodies in peripheral arterial disease. European Journal of Vascular and Endovascular Surgery. Vol. 31, No. 2, pp. 170-175.
    Link to publisher’s version
    https://doi.org/10.1016/j.ejvs.2005.05.044
    Type
    Article
    Collections
    Life Sciences Publications

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