A combined finite-discrete element method for simulating pharmaceutical powder tableting
Publication date
2009-06-09Keyword
Discrete element methodElasticity
Viscoelasticity
Finite element analysis
Pharmaceutical powder
Tableting
Peer-Reviewed
YesOpen Access status
closedAccess
Metadata
Show full item recordAbstract
The pharmaceutical powder and tableting process is simulated using a combined finite-discrete element method and contact dynamics for irregular-shaped particles. The particle-scale formulation and two-stage contact detection algorithm which has been developed for the proposed method enhances the overall calculation efficiency for particle interaction characteristics. The irregular particle shapes and random sizes are represented as a pseudo-particle assembly having a scaled up geometry but based on the variations of real powder particles. Our simulations show that particle size, shapes and material properties have a significant influence on the behaviour of compaction and deformation.Version
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Lewis, R.W., Gethin, D.T., Ysng, X.S. and Rowe, R.C. (2005) A combined finite-discrete element method for simulating pharmaceutical powder tableting. International Journal for Numerical Methods in Engineering. Vol. 62, No 7, pp. 853-869.Link to Version of Record
https://doi.org/10.1002/nme.1287Type
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1002/nme.1287