Functional evidence for cone-specific connectivity in the human retina
Publication date
2009-06-09Keyword
Cardinal chromatic and achromatic mechanismsColour vision
Chromatic opponency
Chromatic sensitivity
Cone selective hypothesis
Random wiring hypothesis
Central vision
Peripheral vision
Peer-Reviewed
YesOpen Access status
closedAccess
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Physiological studies of colour vision have not yet resolved the controversial issue of how chromatic opponency is constructed at a neuronal level. Two competing theories, the cone-selective hypothesis and the random-wiring hypothesis, are currently equivocal to the architecture of the primate retina. In central vision, both schemes are capable of producing colour opponency due to the fact that receptive field centres receive input from a single bipolar cell ¿ the so called `private line arrangement¿. However, in peripheral vision this single-cone input to the receptive field centre is lost, so that any random cone connectivity would result in a predictable reduction in the quality of colour vision. Behavioural studies thus far have indeed suggested a selective loss of chromatic sensitivity in peripheral vision. We investigated chromatic sensitivity as a function of eccentricity for the cardinal chromatic (L/M and S/(L + M)) and achromatic (L + M) pathways, adopting stimulus size as the critical variable. Results show that performance can be equated across the visual field simply by a change of scale (size). In other words, there exists no qualitative loss of chromatic sensitivity across the visual field. Critically, however, the quantitative nature of size dependency for each of the cardinal chromatic and achromatic mechanisms is very specific, reinforcing their independence in terms of anatomy and genetics. Our data provide clear evidence for a physiological model of primate colour vision that retains chromatic quality in peripheral vision, thus supporting the cone-selective hypothesis.Version
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Whitaker, D., McGraw, P. V., McKeefry, D. and Vakrou, C. (2005). Functional evidence for cone-specific connectivity in the human retina. Journal of Physiology. Vol. 566, No. 1, pp. 93-102.Link to Version of Record
https://doi.org/10.1113/jphysiol.2005.084855Type
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1113/jphysiol.2005.084855