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    The hollow fiber assay for drug responsiveness in the Ewing's sarcoma family of tumors

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    Publication date
    2009-05-27T11:21:01Z
    Author
    Bibby, Michael C.
    Bridges, E.M.
    Burchill, S.A.
    Keyword
    Hollow fibre assay
    Clinial trials
    Ewings sarcoma family of tumors
    ESFT
    Doxorubicin
    Anti-cancer agents
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Objective: To investigate the use of the National Cancer Institute's hollow fiber assay (HFA) to evaluate and prioritize novel treatment strategies for clinical trials in the Ewing's sarcoma family of tumors (ESFT). Study design: The growth and morphology of ESFT cell lines in hollow fibers (HFs) was characterized in vitro and in vivo. Reliability and reproducibility were evaluated using doxorubicin. Results: The numbers of viable cells in all 6 ESFT cell lines increased with time in vitro (0 to 96 hours). The SKES-1 and A673 cell lines grew exponentially after implantation of HFs in nude mice at subcutaneous and intraperitoneal sites. ESFT cells formed highly organized distinctive morphology within the HFs in vitro and in vivo. The number of viable ESFT cells within the HFs decreased in a time-dependent (24 to 96 hours) and dose-dependent (1 to 10 mg/kg) manner after treatment with doxorubicin in vivo. Conclusions: The HFA is a versatile short-term in vivo model that may be exploited to predict efficacy of potential anticancer agents in ESFT cells. Tumor markers and pharmacodynamic endpoints may be quantified in the pure population of ESFT cells from within the HFs.
    URI
    http://hdl.handle.net/10454/2703
    Version
    No full-text available in the repository
    Citation
    Bibby, M.C., Bridges, E.M. and Burchill, S.A. (2006). The hollow fiber assay for drug responsiveness in the Ewing's sarcoma family of tumors. Journal of Pediatrics. Vol.149, No.1, pp.103-111.
    Link to publisher’s version
    http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WKR-4KJV498-1H&_user=122861&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000010080&_version=1&_urlVersion=0&_userid=122861&md5=dc392da9e045fc16d6657a379fbe18d4
    Type
    Article
    Collections
    Life Sciences Publications

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