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    Interaction of surfactants (edge activators) and skin penetration enhancers with liposomes.

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    Publication date
    2004
    Author
    Barry, Brian W.
    El-Maghraby, G.M.
    Williams, G.M.
    Keyword
    Surfactants
    Liposomes
    High sensitivity differential scanning calorimetry
    Penetration enhancer
    Edge activators
    Skin
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Incorporating edge activators (surfactants) into liposomes was shown previously to improve estradiol vesicular skin delivery; this phenomenon was concentration dependent with low or high concentrations being less effective. Replacing surfactants with limonene produced similar behaviour, but oleic acid effects were linear with concentration up to 16% (w/w), beyond which it was incompatible with the phospholipid. This present study thus employed high sensitivity differential scanning calorimetry to probe interactions of additives with dipalmitoylphosphatidylcholine (DPPC) membranes to explain such results. Cholesterol was included as an example of a membrane stabiliser that removed the DPPC pre-transition and produced vesicles with a higher transition temperature (Tm). Surfactants also removed the lipid pre-transition but reduced Tm and co-operativity of the main peak. At higher concentrations, surfactants also formed new species, possibly mixed micelles with a lower Tm. The formation of mixed micelles may explain reduced skin delivery from liposomes containing high concentrations of surfactants. Limonene did not remove the pre-transition but reduced Tm and co-operativity of the main peak, apparently forming new species at high concentrations, again correlating with vesicular delivery of estradiol. Oleic acid obliterated the pre-transition. The Tm and the co-operativity of the main peak were reduced with oleic acid concentrations up to 33.2 mol%, above which there was no further change. At higher concentrations, phase separation was evident, confirming previous skin transport findings.
    URI
    http://hdl.handle.net/10454/2694
    Version
    No full-text available in the repository
    Citation
    Barry, B.W., El-Maghraby, G.M.M. and Williams, A.C. (2004) Interaction of surfactants (edge activators) and skin penetration enhancers with liposomes. International journal of pharmaceutics. Vol.276, Nos.1-2, pp.143-161
    Link to publisher’s version
    http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T7W-4C5HT87-3&_user=122861&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000010080&_version=1&_urlVersion=0&_userid=122861&md5=2a0773a52f9896fc87c8c29d0932147e
    Type
    Article
    Collections
    Life Sciences Publications

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