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dc.contributor.authorClark, Brian J.
dc.contributor.authorAltria, K.D.
dc.contributor.authorMahuzier, P.E.
dc.date.accessioned2009-05-18T12:43:04Z
dc.date.available2009-05-18T12:43:04Z
dc.date.issued27/07/2001
dc.identifier.citationMahuzier, P.-E., K.D. Altria, B.J. Clark (2001)Selective and quantitative analysis of 4-hydroxybenzoate preservatives by microemulsion electrokinetic chromatography. Journal of Chromatography A. Volume 924, Issues 1-2, 27 July 2001, pp. 465-470en
dc.identifier.urihttp://hdl.handle.net/10454/2651
dc.descriptionNoen
dc.description.abstractA microemulsion electrokinetic chromatography (MEEKC) method has been developed and validated for the determination of 4-hydroxybenzoates and their impurities. These materials are commonly known as parabens and are widely used as preservatives in foods, cosmetics and pharmaceuticals. The method was shown to be selective and quantitative for the methyl, ethyl, propyl and butyl esters of 4-hydroxybenzoic acid. An internal standard, 4-hydroxyacetophenone, was employed to improve injection precision and detector linearity. In addition, 4-hydroxybenzoic acid, the major degradent, could also be monitored at the 0.1% (m/m) level. The method was successfully validated for assay and detection of the impurities in 4-hydroxybenzoic acid methyl ester and 4-hydroxybenzoic acid propyl ester samples and for the determination of 4-hydroxybenzoic acid methyl ester in a liquid pharmaceutical formulation. The determination of paraben content by MEEKC in a liquid sample was consistent with HPLC analysis. This work is the first reported validated MEEKC method and shows that the methodology can be successfully implemented into routine quality control testing.en
dc.language.isoenen
dc.publisherElsevier Science Directen
dc.relation.isreferencedbyhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TG8-43JXH70-1P&_user=122861&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000010080&_version=1&_urlVersion=0&_userid=122861&md5=9e391e637adeec34e6f3e3a2ac439703en
dc.subjectParabensen
dc.subjectHydroxybenzoic aciden
dc.subjectMicroemulsion electrokinetic chromatographyen
dc.subjectValidationen
dc.titleSelective and quantitative analysis of 4-hydroxybenzoate preservatives by microemulsion electrokinetic chromatographyen
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionNo full-text available in the repositoryen


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