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    Selective and quantitative analysis of 4-hydroxybenzoate preservatives by microemulsion electrokinetic chromatography

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    Publication date
    27/07/2001
    Author
    Clark, Brian J.
    Altria, K.D.
    Mahuzier, P.E.
    Keyword
    Parabens
    Hydroxybenzoic acid
    Microemulsion electrokinetic chromatography
    Validation
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    A microemulsion electrokinetic chromatography (MEEKC) method has been developed and validated for the determination of 4-hydroxybenzoates and their impurities. These materials are commonly known as parabens and are widely used as preservatives in foods, cosmetics and pharmaceuticals. The method was shown to be selective and quantitative for the methyl, ethyl, propyl and butyl esters of 4-hydroxybenzoic acid. An internal standard, 4-hydroxyacetophenone, was employed to improve injection precision and detector linearity. In addition, 4-hydroxybenzoic acid, the major degradent, could also be monitored at the 0.1% (m/m) level. The method was successfully validated for assay and detection of the impurities in 4-hydroxybenzoic acid methyl ester and 4-hydroxybenzoic acid propyl ester samples and for the determination of 4-hydroxybenzoic acid methyl ester in a liquid pharmaceutical formulation. The determination of paraben content by MEEKC in a liquid sample was consistent with HPLC analysis. This work is the first reported validated MEEKC method and shows that the methodology can be successfully implemented into routine quality control testing.
    URI
    http://hdl.handle.net/10454/2651
    Version
    No full-text available in the repository
    Citation
    Mahuzier, P.-E., K.D. Altria, B.J. Clark (2001)Selective and quantitative analysis of 4-hydroxybenzoate preservatives by microemulsion electrokinetic chromatography. Journal of Chromatography A. Volume 924, Issues 1-2, 27 July 2001, pp. 465-470
    Link to publisher’s version
    http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TG8-43JXH70-1P&_user=122861&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000010080&_version=1&_urlVersion=0&_userid=122861&md5=9e391e637adeec34e6f3e3a2ac439703
    Type
    Article
    Collections
    Life Sciences Publications

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