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dc.contributor.authorAhsan, F.
dc.contributor.authorMahmood, T.
dc.contributor.authorWani, T.A.
dc.contributor.authorZargar, S.
dc.contributor.authorSiddiqui, M.H.
dc.contributor.authorUsmani, S.
dc.contributor.authorShamim, A.
dc.contributor.authorWahajuddin, Muhammad
dc.date.accessioned2025-01-30T13:58:31Z
dc.date.accessioned2025-01-31T10:06:59Z
dc.date.available2025-01-30T13:58:31Z
dc.date.available2025-01-31T10:06:59Z
dc.date.issued2022-07-15
dc.identifier.citationAhsan F, Mahmood T, Wani TA et al (2022) Effectual Endeavors of Silk Protein Sericin against Isoproterenol Induced Cardiac Toxicity and Hypertrophy in Wistar Rats. Life. 12(7): 1063.en_US
dc.identifier.issn2075-1729
dc.identifier.urihttp://hdl.handle.net/10454/20231
dc.descriptionYesen_US
dc.description.abstractThe silkworm cocoon has been used in the treatment of various ailments in different Asian countries. This research was designed to evaluate the effect of sericin on myocardial necrosis and hypertrophy in isoproterenol-challenged rats. The rats were administered with sericin (500 and 1000 mg/kg, p.o.) for 28 days, followed by administration of isoprenaline (85 mg/kg, s.c.) on the 29th and 30th days. The cardioprotective activity was assessed by various physical, enzymatic, and histopathological parameters along with apoptotic marker expression. The cardioprotective effect showed that pre-treatment of rats with sericin significantly increased the non-enzymatic antioxidants marker in serum and heart tissue (glutathione, vitamin E, and vitamin C). The results were the same in enzymatic antioxidant marker, mitochondrial enzymes, and protein. The grading of heart, heart/body weight ratio, gross morphology, cardiac markers, oxidative stress markers in serum and heart tissue, glucose, serum lipid profiling and Lysosomal hydrolases, heart apoptotic markers such as MHC expression by western blot, apoptosis by flow cytometry, total myocardial collagen content, fibrosis estimation, myocyte size were significantly decreased when compared with isoproterenol (ISG) group however histopathological studies showed normal architecture of heart in both control and treated rats. The pharmacological study reflects that sericin on both doses i.e., 500 mg/kg and 1000 mg/kg have potent cardioprotective action against the experimental model which was confirmed by various physical, biochemical, and histopathological parameters evaluated further research is required to examine the molecular mechanism of cardioprotective effect of sericin.en_US
dc.description.sponsorshipKing Saud University, Riyadh, Saudi Arabia (RSP-2021/357)en_US
dc.languageen
dc.language.isoenen_US
dc.rights(c) 2022 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/)en_US
dc.subjectSericinen_US
dc.subjectMyocardial infarctionen_US
dc.subjectSilkwormen_US
dc.subjectNecrosisen_US
dc.subjectHypertrophyen_US
dc.subjectIsoproterenolen_US
dc.titleEffectual Endeavors of Silk Protein Sericin against Isoproterenol Induced Cardiac Toxicity and Hypertrophy in Wistar Ratsen_US
dc.status.refereedYesen_US
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.3390/life12071063en_US
dc.rights.licenseCC-BYen_US
dc.date.updated2025-01-30T13:58:32Z
refterms.dateFOA2025-01-31T10:07:22Z
dc.openaccess.statusopenAccessen_US
dc.date.accepted2022-07-07


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