Co-Loading of Black Phosphorus Nanoflakes and Doxorubicin in Lysolipid Temperature-Sensitive Liposomes for Combination Therapy in Prostate Cancer.
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Publication date
2024-01-01Author
Das, ChandrimaMartin, C.
Habermann, S.
Walker, Harriet R.
Iqbal, Javed
Elies, Jacobo

Jones, Huw S.
Reina, G.
Ruiz, Amalia

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(c) 2024 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/)Peer-Reviewed
YesOpen Access status
openAccessAccepted for publication
2023-12-18
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Show full item recordAbstract
Black phosphorus (BP) is one of the most promising nanomaterials for cancer therapy. This 2D material is biocompatible and has strong photocatalytic activity, making it a powerful photosensitiser for combined NIR photothermal and photodynamic therapies. However, the fast degradation of BP in oxic conditions (including biological environments) still limits its use in cancer therapy. This work proposes a facile strategy to produce stable and highly concentrated BP suspensions using lysolipid temperature-sensitive liposomes (LTSLs). This approach also allows for co-encapsulating BP nanoflakes and doxorubicin, a potent chemotherapeutic drug. Finally, we demonstrate that our BP/doxorubicin formulation shows per se high antiproliferative action against an in vitro prostate cancer model and that the anticancer activity can be enhanced through NIR irradiance.Version
Published versionCitation
Das C, Martín C, Habermann S et al (2024) Co-Loading of Black Phosphorus Nanoflakes and Doxorubicin in Lysolipid Temperature-Sensitive Liposomes for Combination Therapy in Prostate Cancer. International Journal of Molecular Sciences. 25(1): 115.Link to Version of Record
https://doi.org/10.3390/ijms25010115Type
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.3390/ijms25010115