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dc.contributor.authorPapalazarou, V.
dc.contributor.authorSwaminathan, Karthic
dc.contributor.authorFarah, J.-H.
dc.contributor.authorSpence, H.
dc.contributor.authorLahmann, I.
dc.contributor.authorNixon, C.
dc.contributor.authorSalmeron-Sanchez, M.
dc.contributor.authorArnold, H.-H.
dc.contributor.authorRottner, K.
dc.contributor.authorMachesky, L.M.
dc.date.accessioned2025-01-03T12:36:27Z
dc.date.accessioned2025-01-06T09:01:23Z
dc.date.available2025-01-03T12:36:27Z
dc.date.available2025-01-06T09:01:23Z
dc.date.issued2020-10-01
dc.identifier.citationPapalazarou V, Swaminathan K, Jaber-Hijazi Fet al (2020) The Arp2/3 complex is critical for colonisation of the mouse skin by melanoblasts. Development. 147: dev194555.en_US
dc.identifier.urihttp://hdl.handle.net/10454/20192
dc.descriptionYesen_US
dc.description.abstractThe Arp2/3 complex is essential for the assembly of branched filamentous actin but its role in physiology and development is surprisingly little understood. Melanoblasts deriving from the neural crest migrate along the developing embryo and traverse the dermis to reach the epidermis colonising the skin and eventually homing within the hair follicles. We have previously established that Rac1 and Cdc42 direct melanoblast migration in vivo We hypothesised that the Arp2/3 complex might be the main downstream effector of these small GTPases. Arp3 depletion in the melanocyte lineage results in severe pigmentation defects in dorsal and ventral regions of the mouse skin. Arp3 null melanoblasts demonstrate proliferation and migration defects and fail to elongate as their wild-type counterparts. Conditional deletion of Arp3 in primary melanocytes causes improper proliferation, spreading, migration and adhesion to extracellular matrix. Collectively, our results suggest that the Arp2/3 complex is absolutely indispensable in the melanocyte lineage in mouse development, and indicate a significant role in developmental processes that require tight regulation of actin-mediated motility.en_US
dc.description.sponsorshipCancer Research UK, (A180076), Medical Research Council (MR/R017255/1), Engineering and Physical Sciences Research Council (EP/P001114/1), Helmholtz-Gemeinschaften_US
dc.languageen
dc.rights(c) 2020 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0)en_US
dc.subjectArp2/3en_US
dc.subjectMelanoblastsen_US
dc.subjectMigrationen_US
dc.subjectActin cytoskeletonen_US
dc.subjectSkin pigmentationen_US
dc.titleThe Arp2/3 complex is critical for colonisation of the mouse skin by melanoblastsen_US
dc.status.refereedYesen_US
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.1242/dev.194555en_US
dc.rights.licenseCC-BYen_US
dc.date.updated2025-01-03T12:36:28Z
refterms.dateFOA2025-01-06T09:01:45Z
dc.openaccess.statusopenAccessen_US
dc.date.accepted2020-09-20


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