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dc.contributor.authorNaveed, S.
dc.contributor.authorDmytriw, A.A.
dc.contributor.authorGhozy, S.
dc.contributor.authorMorsy, Sara
dc.date.accessioned2024-10-02T05:56:21Z
dc.date.accessioned2024-10-02T10:40:21Z
dc.date.available2024-10-02T05:56:21Z
dc.date.available2024-10-02T10:40:21Z
dc.date.issued2024-10
dc.identifier.citationNaveed S, Dmytriw AA, Ghozy S et al (2024) Genetic networks suggest Asperger's syndrome as a distinct subtype of autism spectrum disorders. Research in Autism Spectrum Disorders. 118: 102484.en_US
dc.identifier.urihttp://hdl.handle.net/10454/20023
dc.descriptionYesen_US
dc.description.abstractBackground: The Diagnostic and Statistical Manual of Mental Disorders (DSM-V) issued new diagnostic criteria for autism spectrum disorders (ASD) which resulted in missing the diagnosis of some cases of Asperger’s syndrome (AS). This negatively affected the support received by those affected. In this study, we explored if AS could be biologically stratified from the broader spectrum through a gene co-expression network preservation analysis. Methods: We analysed the GEO microarray data of 24 individuals with Asperger’s syndrome and 72 individuals with autism. Then, we used a weighted gene co-expression network (WGCNA) pipeline to construct gene co-expression networks. We explored whether these modules share the same co-expression patterns between autism and Asperger’s syndrome using network preservation analysis. Results: Our results showed that all co-expression modules of autism are preserved into the Asperger’s syndrome. However, three modules of Asperger’s syndrome out of 30 modules were not preserved in autism. Gene enrichment analysis revealed that these modules were involved in chromatin remodelling, immune and neuroinflammatory response, synaptic and neuronal development. Brain enrichment analysis showed significant downregulation of neurodevelopment genes in different brain regions associated with impaired social recognition in Asperger’s syndrome. Conclusions: The identified genetic and molecular profiles suggest that Asperger’s syndrome, despite sharing numerous similarities with autism, possesses a distinct genetic profile that makes it a distinct subtype of autism. This distinction could have significant implications for the management and treatment strategies tailored to individuals with Asperger’s syndrome.en_US
dc.languageen
dc.language.isoenen_US
dc.rights© 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectAsperger syndromeen_US
dc.subjectAutism spectrum conditionen_US
dc.subjectDSM-Ven_US
dc.subjectWGCNAen_US
dc.subjectWeighted gene correlation networksen_US
dc.titleGenetic networks suggest Asperger’s syndrome as a distinct subtype of autism spectrum disordersen_US
dc.status.refereedYesen_US
dc.date.application2024-09-27
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.1016/j.rasd.2024.102484en_US
dc.rights.licenseCC-BYen_US
dc.date.updated2024-10-02T05:56:34Z
refterms.dateFOA2024-10-02T10:42:19Z
dc.openaccess.statusopenAccessen_US
dc.date.accepted2024-09-14


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