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dc.contributor.authorArthur, Tony B.
dc.contributor.authorRahmanian, Nejat
dc.date.accessioned2024-09-02T15:05:46Z
dc.date.accessioned2024-09-11T13:58:02Z
dc.date.available2024-09-02T15:05:46Z
dc.date.available2024-09-11T13:58:02Z
dc.date.issued2024-06
dc.identifier.citationArthur TB and Rahmanian N (2024) Process simulation of twin-screw granulation: A review. Pharmaceutics. 16(6): 706.en_US
dc.identifier.urihttp://hdl.handle.net/10454/19997
dc.descriptionYesen_US
dc.description.abstractTwin-screw granulation has emerged as a key process in powder processing industries and in the pharmaceutical sector to produce granules with controlled properties. This comprehensive review provides an overview of the simulation techniques and approaches that have been employed in the study of twin-screw granulation processes. This review discusses the major aspects of the twin-screw granulation process which include the fundamental principles of twin-screw granulation, equipment design, process parameters, and simulation methodologies. It highlights the importance of operating conditions and formulation designs in powder flow dynamics, mixing behaviour, and particle interactions within the twin-screw granulator for enhancing product quality and process efficiency. Simulation techniques such as the population balance model (PBM), computational fluid dynamics (CFD), the discrete element method (DEM), process modelling software (PMS), and other coupled techniques are critically discussed with a focus on simulating twin-screw granulation processes. This paper examines the challenges and limitations associated with each simulation approach and provides insights into future research directions. Overall, this article serves as a valuable resource for researchers who intend to develop their understanding of twin-screw granulation and provides insights into the various techniques and approaches available for simulating the twin-screw granulation process.en_US
dc.languageen
dc.language.isoenen_US
dc.rights© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectTwin-screw granulationen_US
dc.subjectSimulationen_US
dc.subjectDiscrete element methoden_US
dc.subjectPopulation balance modelen_US
dc.subjectComputational fluid dynamicsen_US
dc.titleProcess simulation of twin-screw granulation: A reviewen_US
dc.status.refereedYesen_US
dc.date.application2024-05-24
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.3390/pharmaceutics16060706en_US
dc.rights.licenseCC-BYen_US
dc.date.updated2024-09-02T15:05:47Z
refterms.dateFOA2024-09-11T13:59:59Z
dc.openaccess.statusopenAccessen_US
dc.date.accepted2024-05-21


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