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dc.contributor.advisorDrake, Philip
dc.contributor.advisorSwift, Thomas
dc.contributor.advisorAbd-Alhameed, Raed
dc.contributor.authorAlgaddafi, Ali E.
dc.date.accessioned2024-04-04T12:10:56Z
dc.date.available2024-04-04T12:10:56Z
dc.date.issued2022
dc.identifier.urihttp://hdl.handle.net/10454/19870
dc.description.abstractA Magnetic Heating Coil (MHC) has been designed, which has the potential to interact with magnetic Nanoparticles (NPs) to produce local temperature changes. The aim is to design a device capable of studying medically targeted magnetic-fluorescent core-shell NPs (with potential applications in cancer therapy via hyperthermia). Very little is known about how the magnetic-fluorescent NPs respond to magnetic fields and the effect this would have on their optical properties, therefore, considerable work is still required in order to understand the detailed interactions. Several modelling and simulations of the MHC were conducted besides developing the MHC that was designed and built for small samples of NPs (1-10ml volumes). Two different heating coil geometries were examined (coil A and coil B), where the former operates at 83 kHz and the latter operates at 125 kHz. Several tests for fluorescent emission, lifetime and anisotropy with several different NPs samples were conducted. We found that as the temperature increased from 5 °C to 45 °C, the fluorescence lifetime dropped from 3.8 ns to 3.6 ns. Also, the correlation time of the fluorescence in dilute solutions with varying temperatures from 20 °C to 40 °C was investigated, and it was found that decreased from 0.9 ns to 0.6 ns showing that the rotational diffusion of the dye increased and the molecules become more mobile. The MNPs were found to quench the fluorescent emission at high concentrations. Also, the MNPs induce only a small change in a lifetime from 3.9 ns to 3.4 ns.en_US
dc.description.sponsorshipLibyan Higher Ministry of Educationen_US
dc.language.isoenen_US
dc.rights<a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><img alt="Creative Commons License" style="border-width:0" src="http://i.creativecommons.org/l/by-nc-nd/3.0/88x31.png" /></a><br />The University of Bradford theses are licenced under a <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/">Creative Commons Licence</a>.eng
dc.subjectMagnetic heating coil (MHC)en_US
dc.subjectOptical emissionen_US
dc.subjectFluorescenten_US
dc.subjectMagneticen_US
dc.subjectNanoparticlesen_US
dc.subjectLife-timeen_US
dc.subjectAnisotropyen_US
dc.subjectElectronicen_US
dc.subjectHyperthermiaen_US
dc.subjectCoilen_US
dc.subjectInductionen_US
dc.titleDesigning and Building a Novel Magnetic Heating System to Investigate the Dependence of the Magnetic System and the Optical Emission from Nanoparticlesen_US
dc.type.qualificationleveldoctoralen_US
dc.publisher.institutionUniversity of Bradfordeng
dc.publisher.departmentSchool of Chemistry and Biosciences. Faculty of Life Sciencesen_US
dc.typeThesiseng
dc.type.qualificationnamePhDen_US
dc.date.awarded2022
refterms.dateFOA2024-04-04T12:10:56Z


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