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dc.contributor.authorIball, Gareth
dc.contributor.authorBeeching, C.E.
dc.contributor.authorGabe, R.
dc.contributor.authorTam, H.Z.
dc.contributor.authorDarby, M.
dc.contributor.authorCrosbie, P.A.J.
dc.contributor.authorCallister, M.E.J.
dc.date.accessioned2024-01-26T11:52:07Z
dc.date.available2024-01-26T11:52:07Z
dc.date.issued2024-02
dc.identifier.citationIball GR, Beeching CE, Gabe R et al (2024) An evaluation of CT radiation doses within the Yorkshire Lung Screening Trial. British Journal of Radiology. 97(1154): 469-476.
dc.identifier.urihttp://hdl.handle.net/10454/19780
dc.descriptionYes
dc.description.abstractObjectives; To evaluate radiation doses for all low-dose CT scans performed during the first year of a lung screening trial. Methods; For all lung screening scans that were performed using a CT protocol that delivered image quality meeting the RSNA QIBA criteria, , radiation dose metrics, participant height, weight, gender and age were recorded. Values of CTDIvol and DLP were evaluated as a function of weight in order to assess the performance of the scan protocol across the participant cohort. Calculated effective doses were used to establish the additional lifetime attributable cancer risks arising from trial scans. Results; Median values of CTDIvol, DLP and effective dose (IQR) from the 3521 scans were 1.1mGy (0.70), 42.4mGycm (24.9) and 1.15mSv (0.67), whilst for 60-80kg participants the values were 1.0mGy (0.30), 35.8mGycm (11.4) and 0.97mSv (0.31). A statistically significant correlation between CTDIvol and weight was identified for males (r=0.9123, p<0.001) and females (r=0.9052, p<0.001), however the effect of gender on CTDIvol was not statistically significant (p=0.2328) despite notable differences existing at the extremes of the weight range. The additional lifetime attributable cancer risks from a single scan were in the range 0.001-0.006%. Conclusions; Low radiation doses can be achieved across a typical lung screening cohort using scan protocols that have been shown to deliver high levels of image quality. The observed dose levels may be considered as typical values for lung screening scans on similar types of scanner for an equivalent participant cohort. Advances in Knowledge; Presentation of typical radiation dose levels for CT lung screening examinations in a large UK trial. Effective radiation doses can be of the order of 1mSv for standard sized participants. Lifetime attributable cancer risks resulting from a single LDCT scan did not exceed 0.006%.
dc.description.sponsorshipThe Yorkshire Lung Screening Trial is funded by Yorkshire Cancer Research (award reference L403).
dc.language.isoenen
dc.rights© The Author(s) 2023. This is an Open Access article distributed under the Creative Commons CC-BY-NC (https://creativecommons.org/licenses/by-nc/4.0/)
dc.subjectLung cancer screening
dc.subjectCT
dc.subjectDose
dc.subjectLow dose
dc.titleAn evaluation of CT radiation doses within the Yorkshire Lung Screening Trial
dc.status.refereedYes
dc.date.Accepted2023-11-28
dc.date.application2023-12-15
dc.typeArticle
dc.type.versionPublished version
dc.identifier.doihttps://doi.org/10.1093/bjr/tqad045
dc.rights.licenseCC-BY-NC
refterms.dateFOA2024-01-26T11:53:03Z
dc.openaccess.statusopenAccess


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