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dc.contributor.authorEl-Khamisy, Sherif
dc.date.accessioned2023-11-01T15:15:06Z
dc.date.accessioned2023-11-10T13:59:45Z
dc.date.available2023-11-01T15:15:06Z
dc.date.available2023-11-10T13:59:45Z
dc.date.issued2023-11
dc.identifier.citationEl-Khamisy SF (2023) Oxidative DNA damage and repair at non-coding regulatory regions. Trends in Cell Biology. 33(11): 939-949.en_US
dc.identifier.urihttp://hdl.handle.net/10454/19673
dc.descriptionYesen_US
dc.description.abstractDNA breaks at protein-coding sequences are well-established threats to tissue homeostasis and maintenance. They arise from the exposure to intracellular and environmental genotoxins, causing damage in one or two strands of the DNA. DNA breaks have been also reported in non-coding regulatory regions such as enhancers and promoters. They arise from essential cellular processes required for gene transcription, cell identity and function. One such process that has attracted recent attention is the oxidative demethylation of DNA and histones, which generates abasic sites and DNA single-strand breaks. Here, we discuss how oxidative DNA breaks at non-coding regulatory regions are generated and the recently reported role of NuMA (nuclear mitotic apparatus) protein in promoting transcription and repair at these regions.en_US
dc.language.isoenen_US
dc.rights(c) 2023 The Author. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/)en_US
dc.subjectDNA repairen_US
dc.subjectNuMAen_US
dc.subjectDemethylationen_US
dc.subjectEnhancersen_US
dc.subjectPromotersen_US
dc.subjectTranscriptionen_US
dc.titleOxidative DNA damage and repair at non-coding regulatory regionsen_US
dc.status.refereedYesen_US
dc.date.application2023-04-06
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.1016/j.tcb.2023.03.004
dc.rights.licenseCC-BYen_US
dc.date.updated2023-11-01T15:15:07Z
refterms.dateFOA2023-11-10T14:00:04Z
dc.openaccess.statusopenAccessen_US


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