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dc.contributor.authorSpencer, Hannah L.M.
dc.contributor.authorShnyder, Steven D.
dc.contributor.authorLoadman, Paul
dc.contributor.authorFalconer, Robert A.
dc.date.accessioned2023-10-05T12:46:29Z
dc.date.accessioned2023-10-30T12:26:23Z
dc.date.available2023-10-05T12:46:29Z
dc.date.available2023-10-30T12:26:23Z
dc.date.issued2022-01
dc.identifier.citationSpencer HLM, Shnyder SD, Loadman PM et al (2022) The role of MT1-MMP in the progression and metastasis of osteosarcoma. Journal of Cancer Metastasis and Treatment. 8(2).en_US
dc.identifier.urihttp://hdl.handle.net/10454/19637
dc.descriptionYesen_US
dc.description.abstractThe dysregulation of Membrane - type 1 matrix metalloproteinase (MT1-MMP) has been extensively studied in numerous cancer types, and plays key roles in angiogenesis, cancer progression, and metastasis. MT1-MMP is a predictor of poor prognosis in osteosarcoma (OS), yet the molecular mechanisms of disease progression are unclear. This review provides a summary of the literature relating to the gene and protein expression of MT1-MMP (MMP-14) in OS clinical samples, evaluates the expression in cell lines and experimental models, and analyses its potential role in the progression and metastasis of OS. In addition, the therapeutic potential of MT1-MMP as a drug target has been assessed. Due to the biological complexity of MMPs, inhibition has proven to be challenging. However, exploiting the expression and proteolytic capacity of MT1-MMP could open new avenues in the search for novel, safer and selective drugs for use in OS.en_US
dc.description.sponsorshipThis work was supported by the Bone Cancer Research Trust (No. BCRT 6218).en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://dx.doi.org/10.20517/2394-4722.2021.174en_US
dc.rights© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en_US
dc.subjectMatrix metalloproteinaseen_US
dc.subjectMembrane-typeen_US
dc.subjectOsteosarcomaen_US
dc.subjectMT1-MMPen_US
dc.titleThe role of MT1-MMP in the progression and metastasis of osteosarcomaen_US
dc.status.refereedYesen_US
dc.date.Accepted2021-11-16
dc.date.application2022-01-14
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.rights.licenseCC-BYen_US
dc.date.updated2023-10-05T12:46:32Z
refterms.dateFOA2023-10-30T12:27:14Z
dc.openaccess.statusopenAccessen_US


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