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dc.contributor.authorScott, A.
dc.contributor.authorWillis, Craig R.G.
dc.contributor.authorMuratani, M.
dc.contributor.authorHigashitani, A.
dc.contributor.authorEtheridge, T.
dc.contributor.authorSzewczyk, N.J.
dc.contributor.authorDeane, C.S.
dc.date.accessioned2023-08-16T09:25:35Z
dc.date.accessioned2023-08-24T15:07:08Z
dc.date.available2023-08-16T09:25:35Z
dc.date.available2023-08-24T15:07:08Z
dc.date.issued2023-07
dc.identifier.citationScott A, Willis CRG, Muratani M et al (2023) Caenorhabditis elegans in microgravity: An omics perspective. iScience. 26(7): 107189.en_US
dc.identifier.urihttp://hdl.handle.net/10454/19563
dc.descriptionYesen_US
dc.description.abstractThe application of omics to study Caenorhabditis elegans (C. elegans) in the context of spaceflight is increasing, illuminating the wide-ranging biological impacts of spaceflight on physiology. In this review, we highlight the application of omics, including transcriptomics, genomics, proteomics, multi-omics, and integrated omics in the study of spaceflown C. elegans, and discuss the impact, use, and future direction of this branch of research. We highlight the variety of molecular alterations that occur in response to spaceflight, most notably changes in metabolic and neuromuscular gene regulation. These transcriptional features are reproducible and evident across many spaceflown species (e.g., mice and astronauts), supporting the use of C. elegans as a model organism to study spaceflight physiology with translational capital. Integrating tissue-specific, spatial, and multi-omics approaches, which quantitatively link molecular responses to phenotypic adaptations, will facilitate the identification of candidate regulatory molecules for therapeutic intervention and thus represents the next frontiers in C. elegans space omics research.en_US
dc.language.isoenen_US
dc.rights© 2023 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectOmicsen_US
dc.subjectCaenorhabditis elegansen_US
dc.subjectMicrogravityen_US
dc.subjectSpaceflighten_US
dc.subjectPhysiologyen_US
dc.titleCaenorhabditis elegans in microgravity: An omics perspectiveen_US
dc.status.refereedYesen_US
dc.date.Accepted2023
dc.date.application2023-06-20
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.1016/j.isci.2023.107189
dc.rights.licenseCC-BYen_US
dc.date.updated2023-08-16T09:25:38Z
refterms.dateFOA2023-08-24T15:07:48Z
dc.openaccess.statusopenAccessen_US


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