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dc.contributor.authorShriky, Banah
dc.contributor.authorVigato, A.A.
dc.contributor.authorSepulveda, A.F.
dc.contributor.authorMachado, I.P.
dc.contributor.authorRibeiro de Araujo, D.
dc.date.accessioned2023-08-07T11:01:11Z
dc.date.accessioned2023-08-17T12:44:33Z
dc.date.available2023-08-07T11:01:11Z
dc.date.available2023-08-17T12:44:33Z
dc.date.issued2023-08
dc.identifier.citationShriky B, Vigato AA, Sepulveda AF et al (2023) Poloxamer-based nanogels as delivery systems: how structural requirements can drive their biological performance. Biophysical Reviews. 15(4): 475-496.en_US
dc.identifier.urihttp://hdl.handle.net/10454/19554
dc.descriptionYesen_US
dc.description.abstractPoloxamers or Pluronics®-based nanogels are one of the most used matrices for developing delivery systems. Due to their thermoresponsive and flexible mechanical properties, they allowed the incorporation of several molecules including drugs, biomacromolecules, lipid-derivatives, polymers, and metallic, polymeric, or lipid nanocarriers. The thermogelling mechanism is driven by micelles formation and their self-assembly as phase organizations (lamellar, hexagonal, cubic) in response to microenvironmental conditions such as temperature, osmolarity, and additives incorporated. Then, different biophysical techniques have been used for investigating those structural transitions from the mechanisms to the preferential component’s orientation and organization. Since the design of PL-based pharmaceutical formulations is driven by the choice of the polymer type, considering its physico-chemical properties, it is also relevant to highlight that factors inherent to the polymeric matrix can be strongly influenced by the presence of additives and how they are able to determine the nanogels biopharmaceuticals properties such as bioadhesion, drug loading, surface interaction behavior, dissolution, and release rate control. In this review, we discuss the general applicability of three of the main biophysical techniques used to characterize those systems, scattering techniques (small-angle X-ray and neutron scattering), rheology and Fourier transform infrared absorption spectroscopy (FTIR), connecting their supramolecular structure and insights for formulating effective therapeutic delivery systems.en_US
dc.description.sponsorshipThe Sao Paulo Research Foundation - FAPESP (Grant 2019/20303-4; 2019/14773-8), National Council for Scientifc and Technological Development - CNPq (308819/2022-0), ERASMUS Program Fellowship, and The Coordination for the Improvement of Higher Education Personnel - Brazil (CAPES) - Finance Code 001.en_US
dc.language.isoenen_US
dc.publisherspringer
dc.rights© 2023 International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature. Reproduced in accordance with the publisher's self-archiving policy. The final publication is available at Springer via https://doi.org/10.1007/s12551-023-01093-2.en_US
dc.subjectPluronicsen_US
dc.subjectSASen_US
dc.subjectRheologyen_US
dc.subjectFTIRen_US
dc.subjectDrug deliveryen_US
dc.titlePoloxamer-based nanogels as delivery systems: how structural requirements can drive their biological performanceen_US
dc.status.refereedYesen_US
dc.date.Accepted2023-06-30
dc.date.application2023-07-29
dc.typeArticleen_US
dc.date.EndofEmbargo2024-07-29
dc.type.versionAccepted manuscripten_US
dc.description.publicnotesThe full-text of this article will be released for public view at the end of the publisher embargo on 29th July 2024.
dc.identifier.doihttps://doi.org/10.1007/s12551-023-01093-2
dc.rights.licenseUnspecifieden_US
dc.date.updated2023-08-07T11:01:16Z
refterms.dateFOA2023-08-17T12:46:01Z
dc.openaccess.statusembargoedAccessen_US


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