Metal-Free Oxyacetoxylation of Arylynamines and Ynamides to Construct α-Acetoxyl Amides

Long, R.; Huang, S.; Wu, Han-Kui; Iqbal, Naila; Wu, Na

dc.contributor.author	Long, R.
dc.contributor.author	Huang, S.
dc.contributor.author	Wu, Han-Kui
dc.contributor.author	Iqbal, Naila
dc.contributor.author	Wu, Na
dc.date.accessioned	2023-07-13T14:12:00Z
dc.date.accessioned	2023-07-20T09:08:46Z
dc.date.available	2023-07-13T14:12:00Z
dc.date.available	2023-07-20T09:08:46Z
dc.date.issued	2023
dc.identifier.citation	Long R, Huang S, Wu H-K et al (2023) Metal-Free Oxyacetoxylation of Arylynamines and Ynamides to Construct α-Acetoxyl Amides. European Journal of Organic Chemistry. 26(32): e202300393.
dc.identifier.uri	http://hdl.handle.net/10454/19527
dc.description	Yes
dc.description.abstract	Ynamides/arylynamines are challenging substrates for oxyacetoxylation, especially due to various reactive sites of N-heteroaryl ring. Herein we report a metal-free PhI(OAc)2-mediated oxyacetoxylation of arylynamines / ynamides to provide α-acetoxyl amides in good to excellent yields. The transformation completes in a short time to afford solely the product without functionalising N-heteroaryl moiety, in a highly regio- and chemo-selective manner through β-iodo keteneiminium intermediate.
dc.language.iso	en
dc.rights	© 2023 Wiley. This is the peer-reviewed version of the following article: Long R, Huang S, Wu H-K et al (2023) Metal-Free Oxyacetoxylation of Arylynamines and Ynamides to Construct α-Acetoxyl Amides. European Journal of Organic Chemistry. vol 26(32): e202300393 which has been published in final form at https://doi.org/10.1002/ejoc.202300393. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.subject	Ynamides
dc.subject	Arylynamines
dc.subject	Oxyacetoxylation
dc.title	Metal-Free Oxyacetoxylation of Arylynamines and Ynamides to Construct α-Acetoxyl Amides
dc.status.refereed	Yes
dc.date.Accepted	2023-06-27
dc.date.application	2023-06-28
dc.type	Article
dc.type.version	Accepted manuscript
dc.identifier.doi	https://doi.org/10.1002/ejoc.202300393
dc.rights.license	Unspecified
dc.date.updated	2023-07-13T14:12:03Z
refterms.dateFOA	2023-07-20T09:09:20Z
dc.openaccess.status	openAccess