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    The use of silent substitution in measuring isolated cone- & rod- human electroretinograms. An electrophysiological study of human rod- and cone- photoreceptor activity derived using silent substitution paradigm

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    MPhil (7.784Mb)
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    Publication date
    2019
    Author
    Kommanapalli, Deepika
    Supervisor
    McKeefry, Declan J.
    Tripathy, Srimant P.
    Keyword
    Photoreceptor
    Rods
    Cones
    Electroretinogram
    Silent substitution
    Adaptation
    Temporal properties
    Scotopic
    Photopic
    Mesopic
    Parvocellular (PC)
    Magnocellular (MC)
    Koniocellular (KC) post-receptoral pathways
    Colour vision
    Trichromacy
    Dichromats
    Luminance vision
    L/M cone ratios
    Cone contrast
    Retinal illuminance
    Four-primary Ganzfeld stimulator
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    Rights
    Creative Commons License
    The University of Bradford theses are licenced under a Creative Commons Licence.
    Institution
    University of Bradford
    Department
    Bradford School of Optometry and Vision Sciences
    Awarded
    2019
    
    Metadata
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    Abstract
    After over a decade of its discovery, the Electroretinogram (ERG) still remains the objective tool that is conventionally used in assessment of retinal function in health and disease. Although there is ongoing research in developing ERG- recording techniques, interpretation and clinical applications, there is still a limited understanding on how each photoreceptor class contribute to the ERG waveform and their role and/or susceptibilities in various retinal diseases still remains unclear. Another limitation with currently used conventional testing protocols in a clinical setting is the requirement of an adaptation period which is time-consuming. Furthermore, the ERG responses derived in this manner are recorded under different stimulus conditions, thus, making comparison of these signals difficult. To address these issues and develop a new testing method, we employed silent substitution paradigm in obtaining cone- and rod- isolating ERGs using sine- and square- wave temporal profiles. The ERGs achieved in this manner were shown to be photoreceptor-selective. Furthermore, these responses did not only provide the functional index of photoreceptors but their contributions to their successive postreceptoral pathways. We believe that the substitution stimuli used in this thesis could be a valuable tool in functional assessment of individual photoreceptor classes in normal and pathological conditions. Furthermore, we speculate that this method of cone/rod activity isolation could possibly be used in developing faster and efficient photoreceptor-selective testing protocols without the need of adaptation.
    URI
    http://hdl.handle.net/10454/19419
    Type
    Thesis
    Qualification name
    MPhil
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    Theses

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