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dc.contributor.authorSekyi, Nana
dc.contributor.authorKelly, Adrian L.
dc.contributor.authorRahmanian, Nejat
dc.date.accessioned2023-04-14T16:03:48Z
dc.date.accessioned2023-05-03T11:25:24Z
dc.date.available2023-04-14T16:03:48Z
dc.date.available2023-05-03T11:25:24Z
dc.date.issued2023-07
dc.identifier.citationSekyi N, Kelly A and Rahmanian N (2023) Comparative analysis of granule properties in continuous granulators. Powder Technology. 425: 118557.en_US
dc.identifier.urihttp://hdl.handle.net/10454/19412
dc.descriptionYesen_US
dc.description.abstractSeveral contributions in answering granulation challenges including the use of computer simulation and well thought out experimental analyses are being researched. Using a twin screw granulator (TSG) by design of experiments (DoE), comparisons on 1) equipment similarities i.e., continuous and 2) shear forces, are made to previous literature on continuous equipment and a Cyclomix. This study proposes that equipment specific DoE, better explains the contribution of parameters than investigating an identified parameter from the experimental findings from a specific equipment. Granule strength and structure are presented together with the contribution of process parameters, speed, temperature, and binder content. Seeded structures are present in all but the Extrudomix. Longer residence times within the Cyclomix facilitates seeded structures. Granule crushing strengths are higher in TSG than all other continuous equipment. Optimum condition for the formation of stronger granules with least variation is around 65.4 °C.en_US
dc.description.sponsorshipThe authors would like to acknowledge the support from the CCIP grant (Collaboration, Capacity and IP Development) fund from the University of Bradford for ordering cunsumables and equipment.en_US
dc.language.isoenen_US
dc.rights© 2023 The Authors. Published by Elsevier B.V. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.subjectHot melt granulationen_US
dc.subjectTwin screw melt granulationen_US
dc.subjectWet granulationen_US
dc.subjectPolyethylene glycol (PEG) 4000en_US
dc.subjectCalcium carbonate (Durcal 65)en_US
dc.subjectKneading elements (KB)en_US
dc.titleComparative analysis of granule properties in continuous granulatorsen_US
dc.status.refereedYesen_US
dc.date.Accepted2023-04-12
dc.date.application2023-04-14
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.1016/j.powtec.2023.118557
dc.rights.licenseCC-BY-NC-NDen_US
dc.date.updated2023-04-14T16:03:50Z
refterms.dateFOA2023-05-03T11:26:00Z
dc.openaccess.statusopenAccessen_US


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