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    Process simulation of twin-screw granulator: The effect of screw configuration on size distribution

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    Rahmanian_et_al_Chemical_Engineering_and_Technology (389.6Kb)
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    Publication date
    2023
    Author
    Arthur, T.B.
    Sekyi, N.K.G.
    Rahmanian, Nejat
    Pu, Jaan H.
    Keyword
    Agglomerates
    Granule size distribution
    Kneading elements
    Liquid-to-solid ratio
    Twin-screw granulator
    Rights
    © 2023 The Authors. Chemical Engineering Technology published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
    Peer-Reviewed
    Yes
    Open Access status
    openAccess
    
    Metadata
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    Abstract
    The effect of screw configuration on granule size distribution (GSD) using gPROMS FormulatedProduct (gFP) software to perform optimization, estimation of complex processes, and analyses is evaluated. Twin-screw granulation modeling was used to investigate the contribution of screw configuration and liquid-to-solid (L/S) ratio on GSD. Lactose and Avicel were the granulating materials. Twelve different configurations were investigated under three feed rates as consistent with literature and at various L/S ratios. Results indicate that kneading elements promote the recovery of 100–1000 µm granules while reducing the production of oversized granules. Higher feed rates support the production of fines and agglomerates, while a low feed rate produces 100–1000 µm granules.
    URI
    http://hdl.handle.net/10454/19344
    Version
    Published version
    Citation
    Arthur TB, Sekyi NKG, Rahmanian N et al (2023) Process simulation of twin-screw granulator: The effect of screw configuration on size distribution. Chemical Engineering and Technology. Accepted for Publication.
    Link to publisher’s version
    https://doi.org/10.1002/ceat.202200539
    Type
    Article
    Collections
    Engineering and Informatics Publications

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