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    RNA-sequencing muscle plasticity to resistance exercise training and disuse in youth and older age

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    Willis_et_al_Physiologia (723.1Kb)
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    Publication date
    2022-12
    Author
    Fernandez-Gonzalo, R.
    Willis, Craig R.G.
    Etheridge, T.
    Deane, C.S.
    Keyword
    Ageing
    Disuse
    Resistance exercise training
    RNA sequencing
    Skeletal muscle
    Transcriptomics
    Rights
    © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
    Peer-Reviewed
    Yes
    Open Access status
    openAccess
    
    Metadata
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    Abstract
    Maintenance of skeletal muscle mass and function is critical to health and wellbeing throughout the lifespan. However, disuse through reduced physical activity (e.g., sedentarism), immobilisation, bed rest or microgravity has significant adverse effects on skeletal muscle health. Conversely, resistance exercise training (RET) induces positive muscle mass and strength adaptations. Several studies have employed microarray technology to understand the transcriptional basis of muscle atrophy and hypertrophy after disuse and RET, respectively, to devise fully effective therapeutic interventions. More recently, rapidly falling costs have seen RNA-sequencing (RNA-seq) increasingly applied in exploring muscle adaptations to RET and disuse. The aim of this review is to summarise the transcriptional responses to RET or disuse measured via RNA-seq in young and older adults. We also highlight analytical considerations to maximise the utility of RNA-seq in the context of skeletal muscle research. The limited number of muscle transcriptional signatures obtained thus far with RNA-seq are generally consistent with those obtained with microarrays. However, RNA-seq may provide additional molecular insight, particularly when combined with data-driven approaches such as correlation network analyses. In this context, it is essential to consider the most appropriate study design parameters as well as bioinformatic and statistical approaches. This will facilitate the use of RNA-seq to better understand the transcriptional regulators of skeletal muscle plasticity in response to increased or decreased use.
    URI
    http://hdl.handle.net/10454/19315
    Version
    Published version
    Citation
    Fernandez-Gonzalo R, Willis CRG, Etheridge T et al (2022) RNA-sequencing muscle plasticity to resistance exercise training and disuse in youth and older age. Physiologia. 2(4): 164-179.
    Link to publisher’s version
    https://doi.org/10.3390/physiologia2040014
    Type
    Article
    Collections
    Life Sciences Publications

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