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dc.contributor.advisorFalconer, Robert A.
dc.contributor.advisorShnyder, Steven D.
dc.contributor.advisorWright, Colin W.
dc.contributor.authorAbacha, Yabalu Z.
dc.date.accessioned2022-11-09T14:51:05Z
dc.date.available2022-11-09T14:51:05Z
dc.date.issued2020
dc.identifier.urihttp://hdl.handle.net/10454/19205
dc.description.abstractNatural products are acknowledged sources of novel compounds for use in the treatment of diseases such as cancer, malaria, and human African trypanosomiasis. However, health burdens of such diseases still remain high, with drug resistance leading to failure of current medication. Therefore, there is a need for new treatments, and this project considers the potential of Nigerian ethno-medicinal plants and their products. Firstly, the aims were to isolate cytotoxic compounds through bio-guided evaluation and fractionation from 3 medicinal plants; Vitellaria paradoxa, Cyperus articulatus and Securidaca longepedunculata used traditionally in the treatment of cancer in North-East Nigeria. Extracts from S. longepedunculata were the most active when assessed in a panel of cancer cell lines, with IC50 values below 10 µg/ml, whilst fractions isolated from V. paradoxa and C. articulatus were moderately cytotoxic and able to overcome drug resistance mechanisms in drug resistant cell lines. In the second part of the thesis, novel cryptolepine analogues were semi-synthesized using environmentally friendly methods and evaluated for cytotoxic, anti-plasmodial and anti-trypanosomal activity. The compounds were found to be highly cytotoxic in cancer cell lines with the ability to overcome drug resistant mechanisms, with sub-µM IC50 values, and were also active against drug resistant strains of Plasmodium parasites in addition to Trypanosoma brucei, with IC50 values below 500 nM, and 300 pM respectively.en_US
dc.description.sponsorshipSchlumberger Faculty for the Future Foundationen_US
dc.language.isoenen_US
dc.rights<a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><img alt="Creative Commons License" style="border-width:0" src="http://i.creativecommons.org/l/by-nc-nd/3.0/88x31.png" /></a><br />The University of Bradford theses are licenced under a <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/">Creative Commons Licence</a>.eng
dc.subjectMedicinal plantsen_US
dc.subjectCytotoxic natural compoundsen_US
dc.subjectCanceren_US
dc.subjectMalariaen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectCryptolepineen_US
dc.subjectVitellaria paradoxaen_US
dc.subjectCyperus articulatusen_US
dc.subjectSecuridaca longepedunculataen_US
dc.subjectCryptolepis sanguinolentaen_US
dc.titleInvestigation of Nigerian Ethno-medicinal Plants as Potential Sources of Cytotoxic and Anti-plasmodial Compounds. Biological activity of Vitellaria paradoxa, Cyperus articulatus, Securidaca longepedunculata and semi-synthetic halogenated analogues of cryptolepine isolated from Cryptolepis sanguinolentaen_US
dc.type.qualificationleveldoctoralen_US
dc.publisher.institutionUniversity of Bradfordeng
dc.publisher.departmentSchool of Pharmacy and Medical Sciences, Faculty of Life Sciencesen_US
dc.typeThesiseng
dc.type.qualificationnamePhDen_US
dc.date.awarded2020
refterms.dateFOA2022-11-09T14:51:05Z


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