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    Using routine healthcare data to evaluate the impact of the Medicines at Transitions Intervention (MaTI) on clinical outcomes of patients hospitalised with heart failure: protocol for the Improving the Safety and Continuity Of Medicines management at Transitions of care (ISCOMAT) cluster randomised controlled trial with embedded process evaluation, health economics evaluation and internal pilot

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    Powell_et_al_BMJ_Open (605.5Kb)
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    Publication date
    2022-04
    Author
    Moreau, L.A.
    Holloway, I.
    Fylan, Beth
    Hartley, S.
    Cundill, B.
    Fergusson, A.
    Alderson, S.
    Alldred, David P.
    Bojke, C.
    Breen, Liz
    Ismail, Hanif
    Gardner, Peter H.
    Mason, E.
    Powell, Catherine
    Silcock, Jonathan
    Taylor, A.
    Farrin, A.
    Gale, C.
    Show allShow less
    Keyword
    Heart failure
    Heart failure medication
    The Improving the Safety and Continuity Of Medicines management at Transitions (ISCOMAT) trial
    Medicines at Transition Intervention (MaTI)
    Healthcare data
    Rights
    © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
    Peer-Reviewed
    Yes
    Open Access status
    openAccess
    
    Metadata
    Show full item record
    Abstract
    Introduction Heart failure affects 26 million people globally, approximately 900 thousand people in the UK, and is increasing in incidence. Appropriate management of medicines for heart failure at the time of hospital discharge reduces readmissions, improves quality of life and increases survival. The Improving the Safety and Continuity Of Medicines management at Transitions (ISCOMAT) trial tests the effectiveness of the Medicines at Transition Intervention (MaTI), which aims to enhance self-care and increase community pharmacy involvement in the medicines management of heart failure patients. Methods and analysis ISCOMAT is a parallel-group cluster randomised controlled trial, randomising 42 National Health Service trusts with cardiology wards in England on a 1:1 basis to implement the MaTI or treatment as usual. Around 2100 patients over the age of 18 admitted to hospital with heart failure with at least moderate left ventricular systolic dysfunction within the last 5 years, and planned discharge to the geographical area of the cluster will be recruited. The MaTI consists of training for staff, a toolkit for participants, transfer of discharge information to community pharmacies and a medicines reconciliation/review. Treatment as usual is determined by local policy and practices. The primary outcome is a composite of all-cause mortality and heart failure-related hospitalisation at 12 months postregistration obtained from national electronic health records. The key secondary outcome is continued prescription of guideline-indicated therapies at 12 months measured via patient-reported data and Hospital Episode Statistics. The trial contains a parallel mixed-methods process evaluation and an embedded health economics study.
    URI
    http://hdl.handle.net/10454/19192
    Version
    Published version
    Citation
    Moreau LA, Holloway I, Fylan B et al (2022) Using routine healthcare data to evaluate the impact of the Medicines at Transitions Intervention (MaTI) on clinical outcomes of patients hospitalised with heart failure: protocol for the Improving the Safety and Continuity Of Medicines management at Transitions of care (ISCOMAT) cluster randomised controlled trial with embedded process evaluation, health economics evaluation and internal pilot. BMJ Open. 12(4): (e054274).
    Link to publisher’s version
    http://dx.doi.org/10.1136/ bmjopen-2021-054274
    Type
    Article
    Collections
    Life Sciences Publications

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