Concordance of objectively-detected retinal nerve fiber bundle defects in en face OCT images with conventional structural and functional changes in glaucoma.

Abstract

To assess how objectively-detected defects of retinal nerve fibre bundle (RNFB) reflectance in en face OCT images relate to circumpapillary retinal nerve fibre layer thickness (cpRNFLT) and visual field defects. Cross-sectional study. 16 participants with early-glaucoma and 29 age-similar healthy controls, among which 22 had usable en face images to establish normative levels of RNFB reflectance. All participants underwent cpRNFLT scans, visual field examination and wide-field OCT. En face reflectivity was assessed objectively using the Summary of Multiple Anatomically-Adjusted Slabs (SMAS) method. En face defects were deemed concordant with cpRNFLT when they had at least one cpRNFLT point with p