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dc.contributor.authorIsreb, Mohammad
dc.contributor.authorChalkia, Marianiki
dc.contributor.authorGough, Timothy D.
dc.contributor.authorForbes, Robert T.
dc.contributor.authorTimmins, Peter
dc.date.accessioned2022-09-08T13:48:21Z
dc.date.accessioned2022-09-21T13:40:18Z
dc.date.available2022-09-08T13:48:21Z
dc.date.available2022-09-21T13:40:18Z
dc.date.issued2022-08
dc.identifier.citationIsreb M, Chalkia M, Gough TD et al (2022) A Combined Rheological and Thermomechanical Analysis Approach for the Assessment of Pharmaceutical Polymer Blends. Polymers. 4(17): 3527.en_US
dc.identifier.urihttp://hdl.handle.net/10454/19145
dc.descriptionYesen_US
dc.description.abstractThe viscoelastic nature of polymeric formulations utilised in drug products imparts unique thermomechanical attributes during manufacturing and over the shelf life of the product. Nevertheless, it adds to the challenge of understanding the precise mechanistic behaviour of the product at the microscopic and macroscopic level during each step of the process. Current thermomechanical and rheological characterisation techniques are limited to assessing polymer performance to a single phase and are especially hindered when the polymers are undergoing thermomechanical transitions. Since pharmaceutical processing can occur at these transition conditions, this study successfully proposes a thermomechanical characterisation approach combining both mechanical and rheological data to construct a comprehensive profiling of polymeric materials spanning both glassy and rubbery phases. This approach has been used in this study to assess the mechanical and rheological behaviour of heterogenous polymer blends of hydroxypropyl cellulose (HPC) and hydroxypropyl methylcellulose (HPMC) over a shearing rate range of 0.1–100 s−1 and a temperature range of 30–200 °C. The results indicate that HPC and HPMC do not appear to interact when mixing and that their mixture exhibits the mechanistic properties of the two individual polymers in accordance with their ratio in the mixture. The ability to characterise the behaviour of the polymers and their mixtures before, throughout, and after the glassy to rubbery phase transition by application of the combined techniques provides a unique insight towards a quality-by-design approach to this and other polymer-based solid dosage forms, designed with the potential to accelerate their formulation process through obviating the need for multiple formulation trials.en_US
dc.language.isoenen_US
dc.publisherMDPI
dc.rights(c) 2022 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/)en_US
dc.subjectDynamic mechanical analyseren_US
dc.subjectDMAen_US
dc.subjectHydroxypropyl celluloseen_US
dc.subjectMechanical propertiesen_US
dc.subjectPharmaceutical polymersen_US
dc.subjectRheologyen_US
dc.subjectShear rheometeren_US
dc.titleA Combined Rheological and Thermomechanical Analysis Approach for the Assessment of Pharmaceutical Polymer Blendsen_US
dc.status.refereedYesen_US
dc.date.Accepted2022-08-24
dc.date.application2022-08-27
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.3390/polym14173527
dc.rights.licenseCC-BYen_US
dc.date.updated2022-09-08T13:48:24Z
refterms.dateFOA2022-09-21T13:40:39Z
dc.openaccess.statusopenAccessen_US


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