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dc.contributor.advisorParadkar, Anant R.
dc.contributor.advisorKelly, Adrian L.
dc.contributor.authorMohammed, Azad F.
dc.date.accessioned2022-07-27T11:16:33Z
dc.date.available2022-07-27T11:16:33Z
dc.date.issued2020
dc.identifier.urihttp://hdl.handle.net/10454/19075
dc.description.abstractHigh shear melt granulation (HSMG) is an established technology for a production of densified granules. In this project, it was used as a novel solvent-free method for the preparation of cocrystals. Cocrystals produced by HSMG were compared to those prepared by Hot Melt Extrusion (HME) to investigate the influence of variable parameters and conditions on the process of cocrystal conversion. The potential for the active control of cocrystals polymorphism utilising the intrinsic properties of lipids was also investigated in this project. Different cocrystal pairs were prepared by both cocrystallisation methods using glycol derivative polymers. Thermal analysis, powder X-ray diffraction and Raman spectroscopy were used as analytical techniques to determine the cocrystal yield and purity. The results obtained from HSMG suggest that sufficient binder concentrations (above 12.5% w/w) in a molten state and continuous shearing force are necessary to achieve a complete cocrystals conversion. Further increase in binder concentration (15% w/w) was found to provide more regular shape and smooth surface to the prepared spherical granules. Cocrystals preparation by HME was achievable after introducing a mixing zone to the extruder configuration (Conf B and Conf C) providing densified extrudates containing pure cocrystals. In conclusion, HSMG was found as a versatile technique for the preparation of pure pharmaceutical cocrystals embedded in polymer matrix within a spherical shape granule of smooth surfaces, providing additional desirable characteristics. Intensive surface interaction, enhanced by sufficient mixing under optimal parameters, was found as a key influencing factor in cocrystallisation. Cocrystals polymorphism was actively controlled by employing the intrinsic properties of polymers and lipids.en_US
dc.language.isoenen_US
dc.rights<a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><img alt="Creative Commons License" style="border-width:0" src="http://i.creativecommons.org/l/by-nc-nd/3.0/88x31.png" /></a><br />The University of Bradford theses are licenced under a <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/">Creative Commons Licence</a>.eng
dc.subjectSolid-state pharmaceuticsen_US
dc.subjectCrystallisationen_US
dc.subjectCocrystalsen_US
dc.subjectPolymorphismen_US
dc.subjectNeat grindingen_US
dc.subjectHigh shear granulationen_US
dc.subjectHot melt extrusionen_US
dc.subjectTablettingen_US
dc.subjectDissolutionen_US
dc.subjectHigh shear melt granulation (HSMG)en_US
dc.titleA novel solvent-free high shear technology for the preparation of pharmaceutical cocrystalsen_US
dc.type.qualificationleveldoctoralen_US
dc.publisher.institutionUniversity of Bradfordeng
dc.publisher.departmentFaculty of Life Sciencesen_US
dc.typeThesiseng
dc.type.qualificationnamePhDen_US
dc.date.awarded2020
refterms.dateFOA2022-07-27T11:16:33Z


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