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    Biomedical applications of MXene-integrated composites: regenerative medicine, infection therapy, cancer treatment, and biosensing

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    Sefat_et_al_Advanced_Functional_Materials (10.81Mb)
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    Publication date
    2022-08
    Author
    Maleki, A.
    Ghomi, M.
    Nikfarjam, N.
    Akbari, M.
    Sharifi, E.
    Shahbazi, M-A.
    Kermanian, M.
    Seyedhamzeh, M.
    Zare, E.N.
    Mehrali, M.
    Moradi, O.
    Sefat, Farshid
    Mattoli, V.
    Makvandi, P.
    Chen, Y.
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    Keyword
    2D materials
    Biological properties
    Biomedical applications
    Integrated composites
    MXenes
    Rights
    © 2022 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
    Peer-Reviewed
    Yes
    Open Access status
    openAccess
    
    Metadata
    Show full item record
    Abstract
    MXenes (viz., transition metal carbides, carbonitrides, and nitrides) have emerged as a new subclass of 2D materials. Due to their outstanding physicochemical and biological properties, MXenes have gained much attention in the biomedical field in recent years, including drug delivery systems, regenerative medicine, and biosensing. Additionally, the incorporation of MXenes into hydrogels has garnered significant interest in biomedical engineering as an electroactive and mechanical nanoreinforcer capable of converting nonconductive scaffolds into excellent conductors of electricity with an impressive effect on mechanical properties for the engineering of electroactive organs and tissues such as cardiac, skeletal muscle, and nerve. However, many questions and problems remain unresolved that need to be answered to usher these 2D materials toward their true destiny. Thus, this review paper aims to provide an overview of the design and applications of MXene-integrated composites for biomedical applications, including cardiac tissue engineering, wound healing, infection therapy, cancer therapy, and biosensors. Moreover, the current challenges and limitations of utilizing MXenes in vivo are highlighted and discussed, followed by its prospects as a guideline toward possible various futuristic biomedical applications. This review article will inspire researchers, who search for properties, opportunities, and challenges of using this 2D nanomaterial in biomedical applications.
    URI
    http://hdl.handle.net/10454/19055
    Version
    Published version
    Citation
    Maleki A, Ghomi M, Nikfarjam N et al (2022) Biomedical applications of MXene-integrated composites: regenerative medicine, infection therapy, cancer treatment, and biosensing. Advanced Functional Materials. 32(34): 2203430.
    Link to publisher’s version
    https://doi.org/10.1002/adfm.202203430
    Type
    Article
    Collections
    Engineering and Informatics Publications

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