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    Identifying and targeting the molecular signature of smooth muscle cells undergoing early vascular ageing

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    riches-suman_and_hussain_2022.pdf (1.456Mb)
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    Publication date
    2022-07-01
    Author
    Richces-Suman, Kirsten
    Hussain, Alisah
    Keyword
    Smooth muscle cells
    Phenotype
    Early vascular ageing
    Type 2 diabetes
    Abdominal aortic aneurysm
    Hypertension
    Rights
    (c) 2022 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/)
    Peer-Reviewed
    Yes
    Open Access status
    openAccess
    
    Metadata
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    Abstract
    Early vascular ageing (EVA) is a pathological phenomenon whereby the vascular system ages more quickly than chronological age. This underpins many cardiovascular diseases including the complications of type 2 diabetes, aneurysm formation and hypertension. Smooth muscle cells (SMC) are the principal cell type in the vascular wall and maintain vascular tone. EVA-related phenotypic switching of these cells contributes towards disease progression. EVA is distinct from chronological ageing, and research is ongoing to identify a definitive molecular signature of EVA. This will facilitate the discovery of new clinical tests for early detection of EVA and identify therapeutic targets to halt (or prevent) EVA in SMC, thus reducing macrovascular morbidity and mortality.
    URI
    http://hdl.handle.net/10454/18973
    Version
    Published version
    Citation
    Riches-Suman K and Hussain A (2022) Identifying and targeting the molecular signature of smooth muscle cells undergoing early vascular ageing. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1868(7): 166403.
    Link to publisher’s version
    https://doi.org/10.1016/j.bbadis.2022.166403
    Type
    Article
    Collections
    Life Sciences Publications

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