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dc.contributor.authorRamos-Rodriguez, D.H.
dc.contributor.authorPashneh-Tala, S.
dc.contributor.authorBains, A.K.
dc.contributor.authorMoorehead, R.D.
dc.contributor.authorKassos, Nikolaos
dc.contributor.authorKelly, Adrian L.
dc.contributor.authorPaterson, T.E.
dc.contributor.authorOrozco-Diaz, C.A.
dc.contributor.authorGill, A.A.
dc.contributor.authorOrtega Asencio, I.
dc.date.accessioned2022-05-11T07:41:12Z
dc.date.accessioned2022-05-17T12:52:25Z
dc.date.available2022-05-11T07:41:12Z
dc.date.available2022-05-17T12:52:25Z
dc.date.issued2022-04
dc.identifier.citationRamos-Rodriguez DH, Pashneh-Tala S, Bains AK et al (2022) Demonstrating the Potential of Using Bio-Based Sustainable Polyester Blends for Bone Tissue Engineering Applications. Bioengineering. 9(4): 163.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18965
dc.descriptionYesen_US
dc.description.abstractHealthcare applications are known to have a considerable environmental impact and the use of bio-based polymers has emerged as a powerful approach to reduce the carbon footprint in the sector. This research aims to explore the suitability of using a new sustainable polyester blend (Floreon™) as a scaffold directed to aid in musculoskeletal applications. Musculoskeletal problems arise from a wide range of diseases and injuries related to bones and joints. Specifically, bone injuries may result from trauma, cancer, or long-term infections and they are currently considered a major global problem in both developed and developing countries. In this work we have manufactured a series of 3D-printed constructs from a novel biopolymer blend using fused deposition modelling (FDM), and we have modified these materials using a bioceramic (wollastonite, 15% w/w). We have evaluated their performance in vitro using human dermal fibroblasts and rat mesenchymal stromal cells. The new sustainable blend is biocompatible, showing no differences in cell metabolic activity when compared to PLA controls for periods 1-18 days. FloreonTM blend has proven to be a promising material to be used in bone tissue regeneration as it shows an impact strength in the same range of that shown by native bone (just under 10 kJ/m2) and supports an improvement in osteogenic activity when modified with wollastonite.en_US
dc.description.sponsorshipWe would like to acknowledge the Medical Research Council in the UK (MRC) for funding this research throughout a MRC Proximity to Discovery award (P2D) with grant number MC_PC_16084. We would also like to acknowledge CONACYT for funding DH RamosRodriguez’s work.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.3390/bioengineering9040163en_US
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).en_US
dc.subjectSustainabilityen_US
dc.subjectPolyester blenden_US
dc.subjectBiocompatibleen_US
dc.subjectImpact strengthen_US
dc.subjectBone regenerationen_US
dc.titleDemonstrating the Potential of Using Bio-Based Sustainable Polyester Blends for Bone Tissue Engineering Applicationsen_US
dc.status.refereedYesen_US
dc.date.Accepted2022-03-29
dc.date.application2022-04-04
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.rights.licenseCC-BYen_US
dc.date.updated2022-05-11T07:41:14Z
refterms.dateFOA2022-05-17T12:52:52Z
dc.openaccess.statusopenAccessen_US


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