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    Demonstrating the Potential of Using Bio-Based Sustainable Polyester Blends for Bone Tissue Engineering Applications

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    Publication date
    2022-04
    Author
    Ramos-Rodriguez, D.H.
    Pashneh-Tala, S.
    Bains, A.K.
    Moorehead, R.D.
    Kassos, Nikolaos
    Kelly, Adrian L.
    Paterson, T.E.
    Orozco-Diaz, C.A.
    Gill, A.A.
    Ortega Asencio, I.
    Keyword
    Sustainability
    Polyester blend
    Biocompatible
    Impact strength
    Bone regeneration
    Rights
    © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
    Peer-Reviewed
    Yes
    Open Access status
    openAccess
    
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    Abstract
    Healthcare applications are known to have a considerable environmental impact and the use of bio-based polymers has emerged as a powerful approach to reduce the carbon footprint in the sector. This research aims to explore the suitability of using a new sustainable polyester blend (Floreon™) as a scaffold directed to aid in musculoskeletal applications. Musculoskeletal problems arise from a wide range of diseases and injuries related to bones and joints. Specifically, bone injuries may result from trauma, cancer, or long-term infections and they are currently considered a major global problem in both developed and developing countries. In this work we have manufactured a series of 3D-printed constructs from a novel biopolymer blend using fused deposition modelling (FDM), and we have modified these materials using a bioceramic (wollastonite, 15% w/w). We have evaluated their performance in vitro using human dermal fibroblasts and rat mesenchymal stromal cells. The new sustainable blend is biocompatible, showing no differences in cell metabolic activity when compared to PLA controls for periods 1-18 days. FloreonTM blend has proven to be a promising material to be used in bone tissue regeneration as it shows an impact strength in the same range of that shown by native bone (just under 10 kJ/m2) and supports an improvement in osteogenic activity when modified with wollastonite.
    URI
    http://hdl.handle.net/10454/18965
    Version
    Published version
    Citation
    Ramos-Rodriguez DH, Pashneh-Tala S, Bains AK et al (2022) Demonstrating the Potential of Using Bio-Based Sustainable Polyester Blends for Bone Tissue Engineering Applications. Bioengineering. 9(4): 163.
    Link to publisher’s version
    https://doi.org/10.3390/bioengineering9040163
    Type
    Article
    Collections
    Engineering and Informatics Publications

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