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dc.contributor.authorSwift, Thomas
dc.contributor.authorHoskins, Richard
dc.contributor.authorHicks, J.
dc.contributor.authorDyson, Edward
dc.contributor.authorDaignault, M.
dc.contributor.authorBuckle, Dorothy
dc.contributor.authorDouglas, C.W.I.
dc.contributor.authorMacNeil, S.
dc.contributor.authorRimmer, Stephen
dc.date.accessioned2022-03-24T12:35:23Z
dc.date.accessioned2022-04-14T09:29:56Z
dc.date.available2022-03-24T12:35:23Z
dc.date.available2022-04-14T09:29:56Z
dc.date.issued2021-05-17
dc.identifier.citationSwift T, Hoskins R, Hicks J et al (2021) Semi-interpenetrating Polyurethane Network Foams Containing Highly Branched Poly(N-isopropyl acrylamide) with Vancomycin Functionality. ACS Applied Biomaterials. 4(5): 4319-4327.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18886
dc.descriptionYesen_US
dc.description.abstractHighly branched poly(N-isopropylacrylamide) (HB-PNIPAM), functionalized with vancomycin at the chain ends, acted as a bacterial adhesive and was incorporated into polyurethane foams to form semi-interpenetrating networks. The poly(N-isopropylacrylamide) was labelled with a solvatochromic dye, Nile red. It was found that the thermal response of the polymer was dependent on architecture and temperature dependent color changes were observed within the foam. The foams had open pore structures and the presence of the HB-PNIPAM substantially reduced the shrinkage of the foam as the temperature was increased upto 20 °C. The foams were selectively adhesive for Staphylococcus aureus (Gram-positive bacteria) compared to Pseudomonas aeruginosa (Gram-negative bacteria) and the presence of S. aureus was indicated by increased fluorescence intensity (590 to 800 nm).en_US
dc.language.isoenen_US
dc.rights© 2021 The Authors. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Biomaterials, copyright © American Chemical Society after peer-review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsabm.1c00116.en_US
dc.subjectWound dressingen_US
dc.subjectGram-positive bacteriaen_US
dc.subjectvancomycinen_US
dc.subjectPolyurethaneen_US
dc.subjectInterpenetrating networken_US
dc.subjectBranched poly(N-isopropylacrylamide)en_US
dc.titleSemi-interpenetrating Polyurethane Network Foams Containing Highly Branched Poly(N-isopropyl acrylamide) with Vancomycin Functionalityen_US
dc.status.refereedYesen_US
dc.date.Accepted2021-04-08
dc.date.application2021-04-27
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.identifier.doihttps://doi.org/10.1021/acsabm.1c00116
dc.rights.licenseUnspecifieden_US
dc.date.updated2022-03-24T12:35:33Z
refterms.dateFOA2022-04-14T09:30:23Z
dc.openaccess.statusopenAccessen_US


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