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    The effect of PEO homopolymers on the behaviours and structural evolution of Pluronic F127 Smart Hydrogels for Controlled Drug Delivery Systems

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    Publication date
    2022
    Author
    Shriky, Banah
    Mahmoudi, N.
    Kelly, Adrian L.
    Isreb, Mohammad
    Gough, Timothy D.
    Keyword
    Thermosensitive gel
    Thermal properties
    Rheological properties
    Small Angle Neutron Scattering (SANS)
    Drug release
    Colloidal crystals
    Drug delivery systems (DDS)
    Injectables
    Polyethylene glycol (PEG)
    Polyethylene oxide (PEO)
    Smart hydrogels
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    Rights
    © 2022 The Authors. Published by Elsevier. This work is licensed under a Creative Commons Attribution 4.0 International License.
    Peer-Reviewed
    Yes
    Open Access status
    openAccess
    
    Metadata
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    Abstract
    Understanding the structure-property relationships of drug delivery system (DDS) components is critical for their development and the prediction of bodily performance. This study investigates the effects of introducing polyethylene oxide (PEO) homopolymers, over a wide range of molecular weights, into Pluronic injectable smart hydrogel formulations. These smart DDSs promise to enhance patient compliance, reduce adverse effects and dosing frequency. Pharmaceutically, Pluronic systems are attractive due to their unique sol-gel phase transition in the body, biocompatibility, safety and ease of injectability as solutions before transforming into gel matrices at body temperature. This paper presents a systematic and comprehensive evaluation of gelation and the interplay of microscopic and macroscopic properties under both equilibrium and non-equilibrium conditions in controlled environments, as measured by rheology in conjunction with time-resolved Small Angle Neutron Scattering (SANS). The non-equilibrium conditions investigated in this work offer a better understanding of the two polymeric systems’ complex interactions affecting the matrix thermo-rheological behaviour and structure and therefore the future release of an active pharmaceutical ingredient from the injectable DDS.
    URI
    http://hdl.handle.net/10454/18851
    Version
    Published version
    Citation
    Shriky B, Mahmoudi N, Kelly AL et al (2022) The effect of PEO homopolymers on the behaviours and structural evolution of Pluronic F127 Smart Hydrogels for Controlled Drug Delivery Systems. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 645: 128842
    Link to publisher’s version
    https://doi.org/10.1016/j.colsurfa.2022.128842
    Type
    Article
    Collections
    Engineering and Informatics Publications

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