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dc.contributor.advisorMcKeefry, Declan J.
dc.contributor.advisorTripathy, Srimant P.
dc.contributor.advisorBarrett, Brendan T.
dc.contributor.authorKommanapalli, Deepika
dc.date.accessioned2022-03-15T15:19:54Z
dc.date.available2022-03-15T15:19:54Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10454/18779
dc.description.abstractAfter over a decade of its discovery, the Electroretinogram (ERG) still remains the objective tool that is conventionally used in assessment of retinal function in health and disease. Although there is ongoing research in developing ERG recording techniques, interpretation and clinical applications, there is still a limited understanding on how each photoreceptor class contribute to the ERG waveform and their role and/or susceptibilities in various retinal diseases still remains unclear. Another limitation with currently used conventional testing protocols in a clinical setting is the requirement of an adaptation period which is time consuming. Furthermore, the ERG responses derived in this manner are recorded under different stimulus conditions, thus, making comparison of these signals difficult. To address these issues and develop a new testing method, we employed silent substitution paradigm in obtaining cone- and rod- isolating ERGs using sine- and square- wave temporal profiles. The ERGs achieved in this manner were shown to be photoreceptor-selective. Furthermore, these responses did not only provide the functional index of photoreceptors but their contributions to their successive postreceptoral pathways. We believe that the substitution stimuli used in this thesis could be a valuable tool in functional assessment of individual photoreceptor classes in normal and pathological conditions. Furthermore, we speculate that this method of cone/rod activity isolation could possibly be used in developing faster and efficient photoreceptor-selective testing protocols without the need of adaptation.en_US
dc.description.sponsorshipBradford School of Optometry and Vision Sciences scholarshipen_US
dc.language.isoenen_US
dc.rights<a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><img alt="Creative Commons License" style="border-width:0" src="http://i.creativecommons.org/l/by-nc-nd/3.0/88x31.png" /></a><br />The University of Bradford theses are licenced under a <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/">Creative Commons Licence</a>.eng
dc.subjectElectroretinogram (ERG)en_US
dc.subjectCone photoreceptorsen_US
dc.subjectRod photoreceptorsen_US
dc.subjectHuman visionen_US
dc.subjectVision testingen_US
dc.subjectSilent substitutionen_US
dc.titleThe use of Silent Substitution in measuring isolated cone- and rod- Human ERGsen_US
dc.type.qualificationleveldoctoralen_US
dc.publisher.institutionUniversity of Bradfordeng
dc.publisher.departmentFaculty of Life Sciencesen_US
dc.typeThesiseng
dc.type.qualificationnameMPhilen_US
dc.date.awarded2018
refterms.dateFOA2022-03-15T15:19:54Z


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