Longitudinal trajectories of quality of life among people with mild-to-moderate dementia: a latent growth model approach with IDEAL cohort study data
dc.contributor.author | Clare, L. | |
dc.contributor.author | Gamble, L.D. | |
dc.contributor.author | Martyr, A. | |
dc.contributor.author | Sabatini, S. | |
dc.contributor.author | Nelis, S.M. | |
dc.contributor.author | Quinn, Catherine | |
dc.contributor.author | Pentecost, C. | |
dc.contributor.author | Victor, C. | |
dc.contributor.author | Jones, R.W. | |
dc.contributor.author | Jones, I.R. | |
dc.contributor.author | Knapp, M. | |
dc.contributor.author | Litherland, R. | |
dc.contributor.author | Morris, R.G. | |
dc.contributor.author | Rusted, J.M. | |
dc.contributor.author | Thom, J.M. | |
dc.contributor.author | Collins, R. | |
dc.contributor.author | Henderson, C. | |
dc.contributor.author | Matthews, F.E. | |
dc.contributor.author | IDEAL study team | |
dc.date.accessioned | 2022-02-17T12:00:07Z | |
dc.date.accessioned | 2022-03-08T14:40:47Z | |
dc.date.available | 2022-02-17T12:00:07Z | |
dc.date.available | 2022-03-08T14:40:47Z | |
dc.date.issued | 2022-06 | |
dc.identifier.citation | Clare L, Gamble LD, Martyr A et al (2022) Longitudinal trajectories of quality of life among people with mild-to-moderate dementia: a latent growth model approach with IDEAL cohort study data. Journals of Gerontology - Series B Psychological Sciences and Social Sciences. 77(6): 1037-1050. | |
dc.identifier.uri | http://hdl.handle.net/10454/18762 | |
dc.description | Yes | |
dc.description.abstract | Objectives: We aimed to examine change over time in self-rated quality of life (QoL) in people with mild-to-moderate dementia and identify sub-groups with distinct QoL trajectories. Method: We used data from people with mild-to-moderate dementia followed up at 12 and 24 months in the IDEAL cohort study (baseline n=1537). A latent growth model approach examined mean change over time in QoL, assessed with the QoL-AD scale, and investigated associations of baseline demographic, cognitive and psychological covariates with the intercept and slope of QoL. We employed growth mixture modelling to identify multiple growth trajectories. Results: Overall mean QoL scores were stable and no associations with change over time were observed. Four classes of QoL trajectories were identified: two with higher baseline QoL scores, labelled Stable (74.9%) and Declining (7.6%), and two with lower baseline QoL scores, labelled Stable Lower (13.7%) and Improving (3.8%). The Declining class had higher baseline levels of depression and loneliness, and lower levels of self-esteem and optimism, than the Stable class. The Stable Lower class was characterised by disadvantage related to social structure, poor physical health, functional disability, and low psychological well-being The Improving class was similar to the Stable Lower class but had lower cognitive test scores. Discussion: Understanding individual trajectories can contribute to personalised care planning. Efforts to prevent decline in perceived QoL should primarily target psychological well-being. Efforts to improve QoL for those with poorer QoL should additionally address functional impairment, isolation, and disadvantage related to social structure. | |
dc.description.sponsorship | This work was supported by Economic and Social Research Council (ESRC, part of UK Research and Innovation, UKRI) and National Institute for Health Research (NIHR) grant ES/L001853/2. Alzheimer‟s Society Centre of Excellence grant 348, ASPR2-16-001 | |
dc.language.iso | en | en |
dc.rights | © The Author(s) 2022. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/) | |
dc.subject | Alzheimer's | |
dc.subject | Caregivers | |
dc.subject | Longitudinal | |
dc.title | Longitudinal trajectories of quality of life among people with mild-to-moderate dementia: a latent growth model approach with IDEAL cohort study data | |
dc.status.refereed | Yes | |
dc.date.application | 2022-02-03 | |
dc.type | Article | |
dc.type.version | Published version | |
dc.identifier.doi | https://doi.org/10.1093/geronb/gbac022 | |
dc.rights.license | CC-BY | |
dc.date.updated | 2022-02-17T12:00:09Z | |
refterms.dateFOA | 2022-03-08T14:41:19Z | |
dc.openaccess.status | openAccess | |
dc.date.accepted | 2022-01-13 |