Show simple item record

dc.contributor.authorClare, L.
dc.contributor.authorGamble, L.D.
dc.contributor.authorMartyr, A.
dc.contributor.authorSabatini, S.
dc.contributor.authorNelis, S.M.
dc.contributor.authorQuinn, Catherine
dc.contributor.authorPentecost, C.
dc.contributor.authorVictor, C.
dc.contributor.authorJones, R.W.
dc.contributor.authorJones, I.R.
dc.contributor.authorKnapp, M.
dc.contributor.authorLitherland, R.
dc.contributor.authorMorris, R.G.
dc.contributor.authorRusted, J.M.
dc.contributor.authorThom, J.M.
dc.contributor.authorCollins, R.
dc.contributor.authorHenderson, C.
dc.contributor.authorMatthews, F.E.
dc.contributor.authorIDEAL study team
dc.date.accessioned2022-02-17T12:00:07Z
dc.date.accessioned2022-03-08T14:40:47Z
dc.date.available2022-02-17T12:00:07Z
dc.date.available2022-03-08T14:40:47Z
dc.date.issued2022-06
dc.identifier.citationClare L, Gamble LD, Martyr A et al (2022) Longitudinal trajectories of quality of life among people with mild-to-moderate dementia: a latent growth model approach with IDEAL cohort study data. Journals of Gerontology - Series B Psychological Sciences and Social Sciences. 77(6): 1037-1050.
dc.identifier.urihttp://hdl.handle.net/10454/18762
dc.descriptionYes
dc.description.abstractObjectives: We aimed to examine change over time in self-rated quality of life (QoL) in people with mild-to-moderate dementia and identify sub-groups with distinct QoL trajectories. Method: We used data from people with mild-to-moderate dementia followed up at 12 and 24 months in the IDEAL cohort study (baseline n=1537). A latent growth model approach examined mean change over time in QoL, assessed with the QoL-AD scale, and investigated associations of baseline demographic, cognitive and psychological covariates with the intercept and slope of QoL. We employed growth mixture modelling to identify multiple growth trajectories. Results: Overall mean QoL scores were stable and no associations with change over time were observed. Four classes of QoL trajectories were identified: two with higher baseline QoL scores, labelled Stable (74.9%) and Declining (7.6%), and two with lower baseline QoL scores, labelled Stable Lower (13.7%) and Improving (3.8%). The Declining class had higher baseline levels of depression and loneliness, and lower levels of self-esteem and optimism, than the Stable class. The Stable Lower class was characterised by disadvantage related to social structure, poor physical health, functional disability, and low psychological well-being The Improving class was similar to the Stable Lower class but had lower cognitive test scores. Discussion: Understanding individual trajectories can contribute to personalised care planning. Efforts to prevent decline in perceived QoL should primarily target psychological well-being. Efforts to improve QoL for those with poorer QoL should additionally address functional impairment, isolation, and disadvantage related to social structure.
dc.description.sponsorshipThis work was supported by Economic and Social Research Council (ESRC, part of UK Research and Innovation, UKRI) and National Institute for Health Research (NIHR) grant ES/L001853/2. Alzheimer‟s Society Centre of Excellence grant 348, ASPR2-16-001
dc.language.isoenen
dc.rights© The Author(s) 2022. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/)
dc.subjectAlzheimer's
dc.subjectCaregivers
dc.subjectLongitudinal
dc.titleLongitudinal trajectories of quality of life among people with mild-to-moderate dementia: a latent growth model approach with IDEAL cohort study data
dc.status.refereedYes
dc.date.application2022-02-03
dc.typeArticle
dc.type.versionPublished version
dc.identifier.doihttps://doi.org/10.1093/geronb/gbac022
dc.rights.licenseCC-BY
dc.date.updated2022-02-17T12:00:09Z
refterms.dateFOA2022-03-08T14:41:19Z
dc.openaccess.statusopenAccess
dc.date.accepted2022-01-13


Item file(s)

Thumbnail
Name:
Quinn_et_al_JoGPS_Final.pdf
Size:
456.3Kb
Format:
PDF
Thumbnail
Name:
Clare2022LongitudinalPwD.pdf
Size:
786.0Kb
Format:
PDF
Description:
To keep suppressed

This item appears in the following Collection(s)

Show simple item record