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dc.contributor.authorAbdul-Al, Mohamed
dc.contributor.authorKyeremeh, George K.
dc.contributor.authorSaeinasab, M.
dc.contributor.authorHeidari Keshel, S.
dc.contributor.authorSefat, Farshid
dc.date.accessioned2021-12-21T14:44:26Z
dc.date.available2021-12-21T14:44:26Z
dc.date.issued2021-07-28
dc.identifier.citationAbdul-Al M, Kyeremeh GK, Saeinasab M, Heidari Keshel S and Sefat F (2021) Stem Cell Niche Microenvironment: Review. Bioengineering. 8(8): 108.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18693
dc.descriptionyesen_US
dc.description.abstractThe cornea comprises a pool of self‐regenerating epithelial cells that are crucial to preserving clarity and visibility. Limbal epithelial stem cells (LESCs), which live in a specialized stem cell niche (SCN), are crucial for the survival of the human corneal epithelium. They live at the bottom of the limbal crypts, in a physically enclosed microenvironment with a number of neighboring niche cells. Scientists also simplified features of these diverse microenvironments for more analysis in situ by designing and recreating features of different SCNs. Recent methods for regenerating the corneal epithelium after serious trauma, including burns and allergic assaults, focus mainly on regenerating the LESCs. Mesenchymal stem cells, which can transform into self‐renewing and skeletal tissues, hold immense interest in tissue engineering and innovative medicinal exploration. This review summarizes all types of LESCs, identity and location of the human epithelial stem cells (HESCs), reconstruction of LSCN, and artificial stem cells for self‐renewal.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.3390/bioengineering8080108en_US
dc.rights© 2021 the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)en_US
dc.subjectStem cellen_US
dc.subjectNichesen_US
dc.subjectMicroenvironmenten_US
dc.subjectCorneaen_US
dc.subjectLimbal epithelial stem cells (LESCs)en_US
dc.titleStem Cell Niche Microenvironment: Reviewen_US
dc.status.refereedyesen_US
dc.date.Accepted2021-07-16
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2021-12-22T10:12:52Z
dc.openaccess.statusGolden_US


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