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dc.contributor.authorCheloni, R.
dc.contributor.authorDewsbery, S.D.
dc.contributor.authorDenniss, Jonathan
dc.date.accessioned2021-10-11T14:08:48Z
dc.date.accessioned2021-10-20T08:10:27Z
dc.date.available2021-10-11T14:08:48Z
dc.date.available2021-10-20T08:10:27Z
dc.date.issued2021-10-04
dc.identifier.citationCheloni R, Dewsbery SD and Denniss J (2021) Enhanced Objective Detection of Retinal Nerve Fiber Bundle Defects in Glaucoma With a Novel Method for En Face OCT Slab Image Construction and Analysis. Translational Vision Science And Technology. 10(12): 1.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18628
dc.descriptionYesen_US
dc.description.abstractTo introduce and evaluate the performance in detecting glaucomatous abnormalities of a novel method for extracting en face slab images (SMAS), which considers varying individual anatomy and configuration of retinal nerve fiber bundles. Dense central retinal spectral domain optical coherence tomography scans were acquired in 16 participants with glaucoma and 19 age-similar controls. Slab images were generated by averaging reflectivity over different depths below the inner limiting membrane according to several methods. SMAS considered multiple 16 µm thick slabs from 8 to 116 µm below the inner limiting membrane, whereas 5 alternative methods considered single summary slabs of various thicknesses and depths. Superpixels in eyes with glaucoma were considered abnormal if below the first percentile of distributions fitted to control data for each method. The ability to detect glaucoma defects was measured by the proportion of abnormal superpixels. Proportion of superpixels below the fitted first percentile in controls was used as a surrogate false-positive rate. The effects of slab methods on performance measures were evaluated with linear mixed models. The ability to detect glaucoma defects varied between slab methods, χ2(5) = 120.9, Pen_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1167/tvst.10.12.1en_US
dc.rights(c) 2021 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0)en_US
dc.subjectGlaucomaen_US
dc.subjectOptical coherence tomographyen_US
dc.subjectEn faceen_US
dc.subjectRetinal nerve fiber layeren_US
dc.subjectReflectanceen_US
dc.titleEnhanced Objective Detection of Retinal Nerve Fiber Bundle Defects in Glaucoma With a Novel Method for En Face OCT Slab Image Construction and Analysisen_US
dc.status.refereedYesen_US
dc.date.Accepted2021-09-01
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.date.updated2021-10-11T14:08:52Z
refterms.dateFOA2021-10-20T08:11:02Z
dc.openaccess.statusGolden_US


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