Show simple item record

dc.contributor.authorMedlinskiene, Kristina
dc.contributor.authorRichardson, S.
dc.contributor.authorFylan, Beth
dc.contributor.authorStirling, K.
dc.contributor.authorRattray, Marcus
dc.contributor.authorPetty, Duncan
dc.date.accessioned2021-07-06T09:46:42Z
dc.date.accessioned2021-07-21T13:32:31Z
dc.date.available2021-07-06T09:46:42Z
dc.date.available2021-07-21T13:32:31Z
dc.date.issued2021-05-10
dc.identifier.citationMedlinskiene K, Richardson S, Fylan B et al (2021) Patient Perspectives on Factors Affecting Direct Oral Anticoagulant Use for Stroke Prevention in Atrial Fibrillation. Patient Preference and Adherence. 15: 953-966.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18556
dc.descriptionYesen_US
dc.description.abstractIntroduction: Oral anticoagulant therapy choices for patients with atrial fibrillation (AF) expanded in the last decade with the introduction of direct oral anticoagulants (DOAC). However, the implementation of DOACs was slow and varied across different health economies in England. There is limited evidence on the patient role in the uptake of new medicines, including DOACs, apart from considering their demographic and clinical characteristics. Hence, this study aimed to address the gap by exploring the view of patients with AF on factors affecting DOAC use. Methods: A qualitative study using semi-structured interviews was conducted in three health economies in the North of England. Adult patients (>18 years) diagnosed with non-valvular AF, prescribed an oral anticoagulant (vitamin K antagonist or DOAC), and able to give written consent were recruited. Data were collected between August 2018 and April 2019. Audio recorded interviews were transcribed verbatim and analyzed using the framework method. Results: Four themes with eleven subthemes discussed identified factors affecting the use of DOACs. They were linked to limited healthcare financial and workforce resources, patient involvement in decision-making, patient knowledge about DOACs, safety concerns about oral anticoagulants, and oral anticoagulant therapy impact on patients' daily lives. Lack of a) opportunities to voice patient preferences and b) information on available therapy options resulted in some patients experiencing difficulties with the prescribed therapy. This was reported to cause negative impact on their daily lives, adherence, and overall satisfaction with the therapy. Conclusion: Greater patient involvement in decision-making could prevent and resolve difficulties encountered by some patients and potentially improve outcomes plus increase the uptake of DOACs.en_US
dc.description.sponsorshipPharmacy Research UK (PRUK-2018-GA-1-KM) and Leeds Teaching Hospitals NHS Trusten_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.2147/ppa.s302016en_US
dc.rights(c) 2021 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY-NC license.en_US
dc.subjectDOACsen_US
dc.subjectDirect oral anticoagulantsen_US
dc.subjectNew medicinesen_US
dc.subjectShared decision-makingen_US
dc.subjectUptakeen_US
dc.subjectWarfarinen_US
dc.titlePatient Perspectives on Factors Affecting Direct Oral Anticoagulant Use for Stroke Prevention in Atrial Fibrillationen_US
dc.status.refereedYesen_US
dc.date.Accepted2021-03-02
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.date.updated2021-07-06T08:46:51Z
refterms.dateFOA2021-07-21T13:33:12Z
dc.openaccess.statusGolden_US


Item file(s)

Thumbnail
Name:
medlinskiene_et_al_2021.pdf
Size:
516.3Kb
Format:
PDF
Thumbnail
Name:
302016Medlinskieneetal.,2021.doc
Size:
183Kb
Format:
Microsoft Word
Description:
Keep suppressed - Word version

This item appears in the following Collection(s)

Show simple item record