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dc.contributor.authorMcLean, Samantha L.
dc.contributor.authorYun, Haesung
dc.contributor.authorTedder, Andrew
dc.contributor.authorHelfer, Gisela
dc.date.accessioned2021-07-05T17:18:12Z
dc.date.accessioned2021-07-15T10:58:12Z
dc.date.available2021-07-05T17:18:12Z
dc.date.available2021-07-15T10:58:12Z
dc.date.issued2021
dc.identifier.citationMcLean SL, Yun H, Tedder A and Helfer G (2021) The effect of photoperiod and high fat diet on the cognitive response in photoperiod-sensitive F344 rats. Physiology and Behavior. 239: 113496.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18550
dc.descriptionyesen_US
dc.description.abstractIn many species, seasonal changes in day length (photoperiod) have profound effects on physiology and behavior. In humans, these include cognitive function and mood. Here we investigated the effect of photoperiod and high fat diets on cognitive deficits, as measured by novel object recognition, in the photoperiod-sensitive F344 rat, which exhibits marked natural changes in growth, body weight and food intake in response to photoperiod. 32 male juvenile F344 rats were housed in either long or short photoperiod and fed either a high fat or nutrient-matched chow diet. Rats were tested in the novel object recognition test before photoperiod and diet intervention and re-tested 28 days after intervention. In both tests during the acquisition trials there was no significant difference in exploration levels of the left and right objects in the groups. Before intervention, all groups showed a significant increase in exploration of the novel object compared to the familiar object. However, following the photoperiod and diet interventions the retention trial revealed that only rats in the long photoperiod-chow group explored the novel object significantly more than the familiar object, whereas all other groups showed no significant preference. These results suggest that changing rats to short photoperiod impairs their memory regardless of diet. The cognitive performance of rats on long photoperiod-chow remained intact, whereas the high fat diet in the long photoperiod group induced a memory impairment. These findings suggest that rats exposed to long photoperiod have different cognitive responses to rats exposed to short photoperiod and high fat diet.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.physbeh.2021.113496en_US
dc.rights© 2021 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en
dc.subjectPhotoperioden_US
dc.subjectSeasonalen_US
dc.subjectRhythmsen_US
dc.subjectF344en_US
dc.subjectCognitionen_US
dc.subjectHigh fat dieten_US
dc.subjectNovel object recognitionen_US
dc.subjectMemory impairmenten_US
dc.titleThe effect of photoperiod and high fat diet on the cognitive response in photoperiod-sensitive F344 ratsen_US
dc.status.refereedyesen_US
dc.date.Accepted2021-06-09
dc.date.application2021-06-10
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.date.updated2021-07-05T16:18:22Z
refterms.dateFOA2021-07-15T10:58:42Z
dc.openaccess.statusGreen Open Accessen_US


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