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    The effect of photoperiod and high fat diet on the cognitive response in photoperiod-sensitive F344 rats

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    Publication date
    2021
    Author
    McLean, Samantha L.
    Yun, Haesung
    Tedder, Andrew
    Helfer, Gisela
    Keyword
    Photoperiod
    Seasonal
    Rhythms
    F344
    Cognition
    High fat diet
    Novel object recognition
    Memory impairment
    Rights
    © 2021 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
    Peer-Reviewed
    yes
    Open Access status
    Green Open Access
    
    Metadata
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    Abstract
    In many species, seasonal changes in day length (photoperiod) have profound effects on physiology and behavior. In humans, these include cognitive function and mood. Here we investigated the effect of photoperiod and high fat diets on cognitive deficits, as measured by novel object recognition, in the photoperiod-sensitive F344 rat, which exhibits marked natural changes in growth, body weight and food intake in response to photoperiod. 32 male juvenile F344 rats were housed in either long or short photoperiod and fed either a high fat or nutrient-matched chow diet. Rats were tested in the novel object recognition test before photoperiod and diet intervention and re-tested 28 days after intervention. In both tests during the acquisition trials there was no significant difference in exploration levels of the left and right objects in the groups. Before intervention, all groups showed a significant increase in exploration of the novel object compared to the familiar object. However, following the photoperiod and diet interventions the retention trial revealed that only rats in the long photoperiod-chow group explored the novel object significantly more than the familiar object, whereas all other groups showed no significant preference. These results suggest that changing rats to short photoperiod impairs their memory regardless of diet. The cognitive performance of rats on long photoperiod-chow remained intact, whereas the high fat diet in the long photoperiod group induced a memory impairment. These findings suggest that rats exposed to long photoperiod have different cognitive responses to rats exposed to short photoperiod and high fat diet.
    URI
    http://hdl.handle.net/10454/18550
    Version
    Accepted manuscript
    Citation
    McLean SL, Yun H, Tedder A and Helfer G (2021) The effect of photoperiod and high fat diet on the cognitive response in photoperiod-sensitive F344 rats. Physiology and Behavior. 239: 113496.
    Link to publisher’s version
    https://doi.org/10.1016/j.physbeh.2021.113496
    Type
    Article
    Collections
    Life Sciences Publications

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