BRADFORD SCHOLARS

    • Sign in
    View Item 
    •   Bradford Scholars
    • Life Sciences
    • Life Sciences Publications
    • View Item
    •   Bradford Scholars
    • Life Sciences
    • Life Sciences Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Bradford ScholarsCommunitiesAuthorsTitlesSubjectsPublication DateThis CollectionAuthorsTitlesSubjectsPublication Date

    My Account

    Sign in

    HELP

    Bradford Scholars FAQsCopyright Fact SheetPolicies Fact SheetDeposit Terms and ConditionsDigital Preservation Policy

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    View/Open
    Main article (2.153Mb)
    Download
    Publication date
    2021-02
    Author
    Coscolla, M.
    Gagneux, S.
    Menardo, F.
    Loiseau, C.
    Ruiz-Rodriguez, P.
    Borrell, S.
    Otchere, I.D.
    Asante-Poku, A.
    Asare, P.
    Sánchez-Busó, L.
    Gehre, F.
    Sanoussi, C.N.
    Antonio, M.
    Affolabi, D.
    Fyfe, J.
    Beckert, P.
    Niemann, S.
    Alabi, A.S.
    Grobusch, M.P.
    Kobbe, R.
    Parkhill, J.
    Beisel, C.
    Fenner, C.
    Böttger, E.C.
    Meehan, Conor J.
    Harris, S.R.
    de Jong, B.C.
    Yeboah-Manu, D.
    Brites, D.
    Show allShow less
    Keyword
    Mycobacterium africanum
    Mycobacterium tuberculosis
    Diversity
    Evolution
    Genome
    Mycobacterium tuberculosis complex (MTBC)
    Lineages
    Rights
    © 2021 The Authors. This is an Open Access article published by the Microbiology Society, licensed under a Creative Commons Attribution 4.0 International License.
    Peer-Reviewed
    yes
    Open Access status
    Gold
    
    Metadata
    Show full item record
    Abstract
    Human tuberculosis (TB) is caused by members of the Mycobacterium tuberculosis complex (MTBC). The MTBC comprises several human-adapted lineages known as M. tuberculosis sensu stricto, as well as two lineages (L5 and L6) traditionally referred to as Mycobacterium africanum. Strains of L5 and L6 are largely limited to West Africa for reasons unknown, and little is known of their genomic diversity, phylogeography and evolution. Here, we analysed the genomes of 350 L5 and 320 L6 strains, isolated from patients from 21 African countries, plus 5 related genomes that had not been classified into any of the known MTBC lineages. Our population genomic and phylogeographical analyses showed that the unclassified genomes belonged to a new group that we propose to name MTBC lineage 9 (L9). While the most likely ancestral distribution of L9 was predicted to be East Africa, the most likely ancestral distribution for both L5 and L6 was the Eastern part of West Africa. Moreover, we found important differences between L5 and L6 strains with respect to their phylogeographical substructure and genetic diversity. Finally, we could not confirm the previous association of drug-resistance markers with lineage and sublineages. Instead, our results indicate that the association of drug resistance with lineage is most likely driven by sample bias or geography. In conclusion, our study sheds new light onto the genomic diversity and evolutionary history of M. africanum, and highlights the need to consider the particularities of each MTBC lineage for understanding the ecology and epidemiology of TB in Africa and globally.
    URI
    http://hdl.handle.net/10454/18527
    Version
    Published version
    Citation
    Coscolla M, Gagneux S, Menardo F... Mehan CJ... (et al). (2021) Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history. Microbial Genomics. 7 (2).
    Link to publisher’s version
    https://doi.org/10.1099/mgen.0.000477
    Type
    Article
    Collections
    Life Sciences Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.