Show simple item record

dc.contributor.authorSharmin, Nahid
dc.contributor.authorNganwuchu, Chinyere C.
dc.contributor.authorNasim, Md. Talat
dc.date.accessioned2021-05-23T23:05:48Z
dc.date.accessioned2021-06-07T15:10:56Z
dc.date.available2021-05-23T23:05:48Z
dc.date.available2021-06-07T15:10:56Z
dc.date.issued2021-07
dc.identifier.citationSharmin N, Nganwuchu CC and Nasim Md T (2021) Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension. Trends in Pharmacological Sciences. 42(7): 510-513.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18507
dc.descriptionYesen_US
dc.description.abstractAberrant transforming growth factor-β (TGF-β) signaling activation is linked to pulmonary arterial hypertension (PAH). BMPR2 mutations perturb the balance between bone morphogenetic protein (BMP) and TGF-β pathways, leading to vascular remodeling, narrowing of the lumen of pulmonary vasculature, and clinical symptoms. This forum highlights the association of the TGF-β pathway with pathogenesis and therapeutic approaches.en_US
dc.description.sponsorshipResearch carried out at Nasim laboratories is funded by GrowMedtech, the Royal Society, the Commonwealth Scholarship Commission (CSC) and the University of Bradford (UoB). N.S. is funded by the CSC and C.C.N. is partly funded by the UoB.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.tips.2021.04.002en_US
dc.rights© 2021 Elsevier Ltd. All rights reserved. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en_US
dc.subjectPulmonary arterial hypertensionen_US
dc.subjectTGF-βen_US
dc.subjectBMPen_US
dc.subjectPulmonary vasculatureen_US
dc.subjectALK5 inhibitoren_US
dc.titleTargeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertensionen_US
dc.status.refereedYesen_US
dc.date.Accepted2021-04-07
dc.date.application2021-05-06
dc.typeArticleen_US
dc.date.EndofEmbargo2022-05-06
dc.type.versionAccepted manuscripten_US
dc.description.publicnotesThe full-text of this article will be released for public view at the end of the publisher embargo on 06 May 2022.en_US
dc.date.updated2021-05-23T22:05:59Z
refterms.dateFOA2021-06-07T15:11:31Z
dc.openaccess.statusGreenen_US


Item file(s)

Thumbnail
Name:
Nasim_et_al_TPS.pdf
Embargo:
2022-05-06
Size:
298.2Kb
Format:
PDF
Thumbnail
Name:
AcceptedTIPSPAHreview_May2021.docx
Size:
199.8Kb
Format:
Microsoft Word 2007
Description:
To keep suppressed

This item appears in the following Collection(s)

Show simple item record