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dc.contributor.authorBolanle, I.O.
dc.contributor.authorRiches-Suman, Kirsten
dc.contributor.authorWilliamson, Ritchie
dc.contributor.authorPalmer, Timothy M.
dc.date.accessioned2021-05-05T15:12:45Z
dc.date.accessioned2021-05-19T15:35:57Z
dc.date.available2021-05-05T15:12:45Z
dc.date.available2021-05-19T15:35:57Z
dc.date.issued2021-03
dc.identifier.citationBolanle IO, Riches-Suman K, Williamson R, Palmer TM (2021) Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets. Pharmacological Research. 165: 105467en_US
dc.identifier.urihttp://hdl.handle.net/10454/18480
dc.descriptionyesen_US
dc.description.abstractCardiovascular diseases (CVDs) are the leading cause of death globally. While the major focus of pharmacological and non-pharmacological interventions has been on targeting disease pathophysiology and limiting predisposing factors, our understanding of the cellular and molecular mechanisms underlying the pathogenesis of CVDs remains incomplete. One mechanism that has recently emerged is protein O-GlcNAcylation. This is a dynamic, site-specific reversible post-translational modification of serine and threonine residues on target proteins and is controlled by two enzymes: O-linked β-N-acetylglucosamine transferase (OGT) and O-linked β-N-acetylglucosaminidase (OGA). Protein O-GlcNAcylation alters the cellular functions of these target proteins which play vital roles in pathways that modulate vascular homeostasis and cardiac function. Through this review, we aim to give insights on the role of protein O-GlcNAcylation in cardiovascular diseases and identify potential therapeutic targets in this pathway for development of more effective medicines to improve patient outcomes.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.phrs.2021.105467en_US
dc.rights© 2021 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en_US
dc.subjectCardiovascular diseaseen_US
dc.subjectProtein O-GlcNAcylationen_US
dc.subjectO-GlcNAc transferaseen_US
dc.subjectO-GlcNAcaseen_US
dc.titleEmerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targetsen_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.date.EndofEmbargo2022-01-27
dc.type.versionAccepted manuscripten_US
dc.description.publicnotesThe full text will be available at the end of the publisher's embargo: 27th Jan 2022en_US
dc.date.updated2021-05-05T14:12:47Z
refterms.dateFOA2021-05-19T15:41:03Z
dc.openaccess.statusGreenen_US


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