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dc.contributor.authorFarrow, Matthew
dc.contributor.authorGrainger, A.J.
dc.contributor.authorTan, A.L.
dc.contributor.authorBuch, M.H.
dc.contributor.authorEmery, P.
dc.contributor.authorRidgway, J.P.
dc.contributor.authorFeiweier, T.
dc.contributor.authorTanner, S.F.
dc.contributor.authorBiglands, J.
dc.date.accessioned2021-04-27T17:53:31Z
dc.date.accessioned2021-05-18T07:14:30Z
dc.date.available2021-04-27T17:53:31Z
dc.date.available2021-05-18T07:14:30Z
dc.date.issued2019-09
dc.identifier.citationFarrow M, Grainger AJ, Tan AL et al (2019) Normal values and test-retest variability of stimulated-echo diffusion tensor imaging and fat fraction measurements in the muscle. British Journal of Radiology. 92(1101): 20190143.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18470
dc.descriptionYesen_US
dc.description.abstractObjectives: To assess the test-retest variability of both diffusion parameters and fat fraction (FF) estimates in normal muscle, and to assess differences in normal values between muscles in the thigh. Methods: 29 healthy volunteers (mean age 37 years, range 20-60 years, 17/29 males) completed the study. Magnetic resonance images of the mid-thigh were acquired using a stimulated echo acquisition mode-echoplanar imaging (STEAM-EPI) imaging sequence, to assess diffusion, and 2-point Dixon imaging, to assess FF. Imaging was repeated in 19 participants after a 30 min interval in order to assess test-retest variability of the measurements. Results: Intraclass correlation coefficients (ICCs) for test-retest variability were 0.99 [95% confidence interval, (CI): 0.98, 1] for FF, 0.94 (95% CI: 0.84, 0.97) for mean diffusivity and 0.89 (95% CI: 0.74, 0.96) for fractional anisotropy (FA). FF was higher in the hamstrings than the quadriceps by a mean difference of 1.81% (95% CI:1.63, 2.00)%, p < 0.001. Mean diffusivity was significantly lower in the hamstrings than the quadriceps (0.26 (0.13, 0.39) x10-3 mm2s-1, p < 0.001) whereas fractional anisotropy was significantly higher in the hamstrings relative to the quadriceps with a mean difference of 0.063 (0.05, 0.07), p < 0.001. Conclusions: This study has shown excellent test-retest, variability in MR-based FF and diffusion measurements and demonstrated significant differences in these measures between hamstrings and quadriceps in the healthy thigh. Advances in knowledge: Test-retest variability is excellent for STEAM-EPI diffusion and 2-point Dixon-based FF measurements in the healthy muscle. Inter- and intraobserver variability were excellent for region of interest placement for STEAM-EPI diffusion and 2-point Dixon-based FF measurements in the healthy muscle. There are significant differences in FF and diffusion measurements between the hamstrings and quadriceps in the normal muscle.en_US
dc.description.sponsorshipICA-CL-2016-02-017/DH_/Department of Health/United Kingdom; NIHRen_US
dc.language.isoenen_US
dc.rights(c) 2019 The Authors.en_US
dc.subjectDiffusion tensor imagingen_US
dc.subjectDTIen_US
dc.subjectSkeletal muscleen_US
dc.subjectMyositisen_US
dc.subjectDiabetes mellitusen_US
dc.subjectMuscle injuryen_US
dc.subjectSTEAMen_US
dc.subjectStimulated echo acquisition modeen_US
dc.titleNormal values and test-retest variability of stimulated-echo diffusion tensor imaging and fat fraction measurements in the muscleen_US
dc.status.refereedYesen_US
dc.date.Accepted2019-06-30
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.1259/bjr.20190143
dc.date.updated2021-04-27T16:53:32Z
refterms.dateFOA2021-05-18T07:14:48Z
dc.openaccess.statusGolden_US


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