Normal values and test-retest variability of stimulated-echo diffusion tensor imaging and fat fraction measurements in the muscle
dc.contributor.author | Farrow, Matthew | |
dc.contributor.author | Grainger, A.J. | |
dc.contributor.author | Tan, A.L. | |
dc.contributor.author | Buch, M.H. | |
dc.contributor.author | Emery, P. | |
dc.contributor.author | Ridgway, J.P. | |
dc.contributor.author | Feiweier, T. | |
dc.contributor.author | Tanner, S.F. | |
dc.contributor.author | Biglands, J. | |
dc.date.accessioned | 2021-04-27T17:53:31Z | |
dc.date.accessioned | 2021-05-18T07:14:30Z | |
dc.date.available | 2021-04-27T17:53:31Z | |
dc.date.available | 2021-05-18T07:14:30Z | |
dc.date.issued | 2019-09 | |
dc.identifier.citation | Farrow M, Grainger AJ, Tan AL et al (2019) Normal values and test-retest variability of stimulated-echo diffusion tensor imaging and fat fraction measurements in the muscle. British Journal of Radiology. 92(1101): 20190143. | en_US |
dc.identifier.uri | http://hdl.handle.net/10454/18470 | |
dc.description | Yes | en_US |
dc.description.abstract | Objectives: To assess the test-retest variability of both diffusion parameters and fat fraction (FF) estimates in normal muscle, and to assess differences in normal values between muscles in the thigh. Methods: 29 healthy volunteers (mean age 37 years, range 20-60 years, 17/29 males) completed the study. Magnetic resonance images of the mid-thigh were acquired using a stimulated echo acquisition mode-echoplanar imaging (STEAM-EPI) imaging sequence, to assess diffusion, and 2-point Dixon imaging, to assess FF. Imaging was repeated in 19 participants after a 30 min interval in order to assess test-retest variability of the measurements. Results: Intraclass correlation coefficients (ICCs) for test-retest variability were 0.99 [95% confidence interval, (CI): 0.98, 1] for FF, 0.94 (95% CI: 0.84, 0.97) for mean diffusivity and 0.89 (95% CI: 0.74, 0.96) for fractional anisotropy (FA). FF was higher in the hamstrings than the quadriceps by a mean difference of 1.81% (95% CI:1.63, 2.00)%, p < 0.001. Mean diffusivity was significantly lower in the hamstrings than the quadriceps (0.26 (0.13, 0.39) x10-3 mm2s-1, p < 0.001) whereas fractional anisotropy was significantly higher in the hamstrings relative to the quadriceps with a mean difference of 0.063 (0.05, 0.07), p < 0.001. Conclusions: This study has shown excellent test-retest, variability in MR-based FF and diffusion measurements and demonstrated significant differences in these measures between hamstrings and quadriceps in the healthy thigh. Advances in knowledge: Test-retest variability is excellent for STEAM-EPI diffusion and 2-point Dixon-based FF measurements in the healthy muscle. Inter- and intraobserver variability were excellent for region of interest placement for STEAM-EPI diffusion and 2-point Dixon-based FF measurements in the healthy muscle. There are significant differences in FF and diffusion measurements between the hamstrings and quadriceps in the normal muscle. | en_US |
dc.description.sponsorship | ICA-CL-2016-02-017/DH_/Department of Health/United Kingdom; NIHR | en_US |
dc.language.iso | en | en_US |
dc.rights | (c) 2019 The Authors. | en_US |
dc.subject | Diffusion tensor imaging | en_US |
dc.subject | DTI | en_US |
dc.subject | Skeletal muscle | en_US |
dc.subject | Myositis | en_US |
dc.subject | Diabetes mellitus | en_US |
dc.subject | Muscle injury | en_US |
dc.subject | STEAM | en_US |
dc.subject | Stimulated echo acquisition mode | en_US |
dc.title | Normal values and test-retest variability of stimulated-echo diffusion tensor imaging and fat fraction measurements in the muscle | en_US |
dc.status.refereed | Yes | en_US |
dc.date.Accepted | 2019-06-30 | |
dc.type | Article | en_US |
dc.type.version | Published version | en_US |
dc.identifier.doi | https://doi.org/10.1259/bjr.20190143 | |
dc.date.updated | 2021-04-27T16:53:32Z | |
refterms.dateFOA | 2021-05-18T07:14:48Z | |
dc.openaccess.status | Gold | en_US |