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dc.contributor.authorFarrow, Matthew
dc.contributor.authorBiglands, J.D.
dc.contributor.authorGrainger, A.J.
dc.contributor.authorO'Connor, P.
dc.contributor.authorHensor, E.M.A.
dc.contributor.authorLadas, A.
dc.contributor.authorTanner, S.F.
dc.contributor.authorEmergy, P.
dc.contributor.authorTan, A.L.
dc.date.accessioned2021-04-27T17:51:30Z
dc.date.accessioned2021-05-13T07:44:28Z
dc.date.available2021-04-27T17:51:30Z
dc.date.available2021-05-13T07:44:28Z
dc.date.issued2021-01-01
dc.identifier.citationFarrow M, Biglands JD, Grainger AJ et al (2021) Quantitative MRI in myositis patients: comparison with healthy volunteers and radiological visual assessment. Clinical Radiology. 76(1): 81.e1-81.e10.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18462
dc.descriptionYesen_US
dc.description.abstractTo assess whether magnetic resonance imaging (MRI)-based measurements of T2, fat fraction, diffusion tensor imaging, and muscle volume can detect differences between the muscles of myositis patients and healthy controls, and to identify how they compare with semi-quantitative MRI diagnosis. Sixteen myositis patients and 16 age- and gender-matched healthy controls underwent MRI of their thigh. Quantitative MRI measurements and radiologists' semi-quantitative scores were assessed. Strength was assessed using an isokinetic dynamometer. Fat fraction and T2 values were higher in myositis patients whereas muscle volume was lower compared to healthy controls. There was no difference in diffusion. Muscle strength was lower in myositis patients compared to healthy controls. In a subgroup of eight patients, scored as unaffected by radiologists, T2 values were still significantly higher in myositis patients. Quantitative MRI measurements can detect differences between myositis patients and healthy controls. Changes in the muscles of myositis patients, undetected by visual, semi-quantitative scoring, can be detected using quantitative T2 measurements. This suggests that MRI T2 values may be useful for the management of myositis patients.en_US
dc.description.sponsorshipNational Institute for Health Research (NIHR) Leeds (BRC) and Health Education Englanden_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.crad.2020.08.022en_US
dc.rights(c) 2021 The Royal College of Radiologists. This is an Open Access article distributed under the Creative Commons CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en_US
dc.subjectMyositisen_US
dc.subjectQuantitative MRIen_US
dc.titleQuantitative MRI in myositis patients: comparison with healthy volunteers and radiological visual assessmenten_US
dc.status.refereedYesen_US
dc.date.Accepted2020-08-21
dc.date.application2020-09-18
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.date.updated2021-04-27T16:51:40Z
refterms.dateFOA2021-05-13T07:48:14Z
dc.openaccess.statusGolden_US


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